Temporal changes in vocal functions of human scarred vocal folds after cordectomy

The Laryngoscope
Yo KishimotoJuichi Ito

Abstract

The maturation process of scarred vocal folds has previously been investigated using animal models. However, in human models the features of scarred vocal folds have rarely been described, and the process by which the scar changes with time is not well known. The present study aimed to investigate the maturation process of human vocal folds scarred by cordectomy in terms of vibratory and aerodynamic functions. Prospective case series. Eight patients with early glottic carcinoma and two patients with leukoplakia of the vocal fold underwent endoscopic cordectomy at Kyoto University Hospital between 2006 and 2008. The temporal changes in their vocal functions were evaluated using acoustic and aerodynamic analyses and videostroboscopic examination. Normalized mucosal wave amplitude, mean flow rate, and the amplitude perturbation quotient appear to stabilize about 6 months after the procedure. Although there were individual variations in the changes in normalized glottal gap and maximum phonation time, it appears to take at least 6 months to reach plateau. The other parameters-pitch perturbation quotient and noise to harmonic ratio-varied by individual, and thus it was difficult to identify commonalities in the healing process. Some...Continue Reading

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Sep 22, 2010·Current Opinion in Otolaryngology & Head and Neck Surgery·Yo KishimotoShigeru Hirano
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