Temporal clustering of neuroblastic tumours in children and young adults from Northern England

Environmental Health : a Global Access Science Source
C R MuirheadRichard J Q McNally

Abstract

The aetiology of neuroblastic tumours is unclear with both genetic and environmental factors implicated. The possibility that an infectious agent may be involved has been suggested. 'Temporal clustering' occurs if cases display an irregular temporal distribution and may indicate the involvement of an agent that exhibits epidemicity. We tested for the presence and nature of temporal clustering using population-based data from northern England. We extracted all cases of neuroblastic tumours diagnosed in children and young adults aged 0-24 years during 1968-2011 from the Northern Region Young Persons' Malignant Disease Registry. This is a population-based registry, covering a population of approximately 900,000 young persons, and includes all cases resident in northern England at the time of diagnosis. Tests for temporal clustering were applied using a modified version of the Potthoff-Whittinghill method. Estimates of extra-Poisson variation (β) and standard errors (SEs) were obtained. 227 cases of neuroblastic tumours were diagnosed during the study period. All the analyses between fortnights and between months found significant extra-Poisson variation, with β = 0.846 (SE = 0.310, P = 0.004) for the analysis between fortnights wi...Continue Reading

References

Jun 1, 1966·Biometrika·R F Potthoff, M Whittinghill
Jun 1, 1966·Biometrika·R F Potthoff, M Whittinghill
Aug 1, 1993·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·G M BrodeurF Hedborg
May 15, 1996·American Journal of Epidemiology·A M MichalekM C Mahoney
Apr 30, 1996·Proceedings of the National Academy of Sciences of the United States of America·M W OllertC W Vogel
Jan 1, 1997·Archives of Disease in Childhood·D SatgeC A Stiller
Mar 28, 1998·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·K DavidC W Vogel
Mar 28, 1998·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·R P CastleberryJ J Shuster
Oct 3, 1999·British Journal of Cancer·J A RossL L Robison
Dec 22, 1999·International Journal of Cancer. Journal International Du Cancer·V B SmulevichS V Belyakova
Jan 5, 2000·Cancer Causes & Control : CCC·A F OlshanR P Castleberry
May 16, 2000·Occupational and Environmental Medicine·T Pless-MulloliR Darnell
Jan 4, 2001·Epidemiology·J L DanielsR P Castleberry
Mar 10, 2001·Paediatric and Perinatal Epidemiology·G M BuckM S Baptiste
Jul 12, 2001·American Journal of Epidemiology·A J De RoosB H Pollock
Jul 31, 2002·Cancer Causes & Control : CCC·Julie L DanielsDaniel O Stram
Aug 23, 2002·Epidemiology·Andrew F OlshanBrad H Pollock
Nov 28, 2002·International Journal of Cancer. Journal International Du Cancer·Richard J Q McNallyJillian M Birch
Sep 11, 2003·Clinical Pharmacology and Therapeutics·Amy E FrenchGideon Koren
Mar 17, 2004·American Journal of Human Genetics·Delphine TrochetJeanne Amiel
Mar 31, 2004·American Journal of Epidemiology·Michael N CookBrad H Pollock
Apr 24, 2004·American Journal of Epidemiology·Florence MenegauxMelissa L Bondy
Nov 18, 2004·Pediatric Blood & Cancer·Florence MenegauxSusan L Cohn
Jul 29, 2005·Cancer Causes & Control : CCC·Erin E McCallJulie L Daniels
Dec 29, 2005·International Journal of Cancer. Journal International Du Cancer·Richard J Q McNallyJohn F Bithell
Apr 25, 2006·Cancer Causes & Control : CCC·Elizabeth C BluhmUNKNOWN Children's Oncology Group (United States)
Aug 5, 2006·Statistical Methods in Medical Research·Colin R Muirhead
Dec 21, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Christina M CoughlinRobert H Vonderheide
Feb 8, 2007·Cancer·Eric J ChowBeth A Mueller
Feb 23, 2007·Clinical Pharmacology and Therapeutics·Y I GohG Koren
Mar 3, 2007·Cancer Treatment Reviews·Charles A Stiller
Mar 9, 2007·European Journal of Pediatrics·Joachim SchüzPeter Kaatsch
Dec 13, 2007·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Claire Infante-Rivard, Mariam El-Zein
Dec 14, 2007·International Journal of Cancer. Journal International Du Cancer·Caroline MunzerJacqueline Clavel
Jun 12, 2008·International Journal of Cancer. Journal International Du Cancer·Kimberly J JohnsonLogan G Spector
Sep 19, 2008·International Journal of Cancer. Journal International Du Cancer·Elizabeth BluhmJoseph F Fraumeni
Oct 11, 2008·International Journal of Cancer. Journal International Du Cancer·Richard J Q McNallyMichael F G Murphy
Oct 23, 2008·Cancer Causes & Control : CCC·Colleen C McLaughlinPhilip C Nasca
Nov 28, 2008·International Journal of Cancer. Journal International Du Cancer·Richard J Q McNallyMichael F G Murphy
Jan 23, 2009·Paediatric and Perinatal Epidemiology·Julia E HeckPaolo Boffetta
Feb 2, 2010·Hematology/oncology Clinics of North America·Julie R ParkHuib Caron

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

International Journal of Cancer. Journal International Du Cancer
Richard J Q McNallyMichael F G Murphy
Pathology Oncology Research : POR
Tibor A NyariRichard J Q McNally
European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
Richard J Q McNallyJillian M Birch
© 2021 Meta ULC. All rights reserved