Temporal course of changes in gene expression suggests a cytokine-related mechanism for long-term hippocampal alteration after controlled cortical impact

Journal of Neurotrauma
Camila P Almeida-SuhettLee E Eiden

Abstract

Mild traumatic brain injury (mTBI) often has long-term effects on cognitive function and social behavior. Altered gene expression may be predictive of long-term psychological effects of mTBI, even when acute clinical effects are minimal or transient. Controlled cortical impact (CCI), which causes concussive, but nonpenetrant, trauma to underlying (non-cortical) brain, resulting in persistent changes in hippocampal synaptic function, was used as a model of mTBI. The hippocampal transcriptomes of sham-operated or injured male rats at 1, 7, and 30 days postinjury were examined using microarrays comprising a comprehensive set of expressed genes, subsequently confirmed by quantitative reverse-transcriptase polymerase chain reaction. Transcripts encoding the chemokines, chemokine (C-C motif) ligand (Ccl)2 and Ccl7, inflammatory mediators lipocalin-2 (Lcn2) and tissue inhibitor of metalloproteinase 1 (Timp1), immunocyte activators C-C chemokine receptor type 5 (Ccr5) and Fc fragment of IgG, low affinity IIb, receptor (CD32) (Fcgr2b), the major histocompatibility complex II immune response-related genes, Cd74 and RT1 class II, locus Da (RT1-Da), the complement component, C3, and the transcription factor, Kruppel-like factor 4 (Klf4), w...Continue Reading

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Citations

Apr 2, 2016·Journal of Neurotrauma·Kian Merchant-BornaJeffrey J Bazarian
Dec 17, 2014·Neuroscience and Biobehavioral Reviews·Mithilesh Kumar JhaKyoungho Suk
Nov 12, 2016·Experimental Neurology·Ryan S SprisslerMichael F Hammer
Aug 9, 2019·Journal of Neuroendocrinology·Kanokporn PinyopornpanishSiriporn C Chattipakorn
Sep 7, 2019·Journal of Translational Medicine·Birte WeberMiriam Kalbitz
Sep 23, 2020·Pharmaceutical Patent Analyst·Hermann Am Mucke
Aug 24, 2019·Frontiers in Cellular Neuroscience·Saef IzzyMichael J Whalen
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Mar 9, 2019·Cellular & Molecular Immunology·Kaibin ShiFu-Dong Shi
Feb 5, 2021·CNS Neuroscience & Therapeutics·Nurul Atiqah ZulazmiMohd Farooq Shaikh
Jul 30, 2021·Ageing Research Reviews·Doortje W DekensPetrus J W Naudé

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Methods Mentioned

BETA
dissector
in vitro transcription
Chip
chips

Software Mentioned

MicroBrightField
StereoInvestigator
Primer
Partek Genomic suite

Related Concepts

Related Feeds

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.