PMID: 8587801Jan 1, 1996Paper

Temporal differences in praziquantel- and oxamniquine-induced tegumental damage to adult Schistosoma mansoni: implications for drug-antibody synergy

Parasitology
P G FallonG A Wharton

Abstract

A temporal study of the effects on the tegument of Schistosoma mansoni adult worm following in vivo praziquantel and oxamniquine treatment was performed. Drug-induced damage to the tegument, exposure of surface antigens and attachment of host antibody occurred rapidly, within 1 h, following praziquantel treatment. Oxamniquine-treated worms required 4-8 days for these effects to be apparent. The 2 drugs differed in the degree and sites of damage on the worm surface. The administration of 2 different polyspecific rabbit sera with drug significantly increased the efficacy of praziquantel when administered with the drug, but not when given 6-9 days after drug treatment. In contrast, only 1 serum was synergistic with oxamniquine when administered with drug and both sera were synergistic when given 6-9 days after drug treatment. The effect of immune killing of drug-treated worms is discussed.

References

Jan 1, 1992·Parasitology
Jan 1, 1992·Parasitology·P G FallonM J Doenhoff
May 1, 1989·Transactions of the Royal Society of Tropical Medicine and Hygiene·J R LambertucciM Doenhoff
Jan 1, 1987·Transactions of the Royal Society of Tropical Medicine and Hygiene·M J DoenhoffJ Bain
Dec 1, 1985·Experimental Parasitology·A A SabahM J Doenhoff
Oct 1, 1992·Parasitology Today·T A DayR A Pax
Nov 1, 1992·Parasitology Today·P Marsden
May 1, 1993·Parasitology Today·D CioliS Archer

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Citations

Jun 25, 2013·Micron : the International Research and Review Journal for Microscopy·Shyamashree DasguptaBishnupada Roy
Oct 8, 2013·Parasitology Research·Serry A El BialyHassan M Essa
Jan 5, 2012·Parasitology Research·Humberto Gonçalves BertãoGandhi Rádis-Baptista
Mar 4, 2009·Parasitology Research·Rashad Abdul-GhaniAzza Hassan
Dec 18, 2003·Cellular Microbiology·Paul G Thomas, Donald A Harn
Aug 15, 2006·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·P G Fallon
Jun 7, 2003·Parasite Immunology·Francisca MutapiPatricia D Ndhlovu
Nov 9, 2010·International Journal for Parasitology·Maha M EissaNahed M Baddour
Jun 2, 2011·PLoS Neglected Tropical Diseases·Debalina Ray, David L Williams
Jan 12, 2007·PLoS Medicine·Maha-Hamadien AbdullaConor R Caffrey
Aug 19, 2009·PLoS Neglected Tropical Diseases·Sandra D MelmanEric S Loker
Sep 29, 2011·PLoS Neglected Tropical Diseases·Michael WoelfleMatthew H Todd
Aug 27, 2009·PLoS Neglected Tropical Diseases·Brett E Swierczewski, Stephen J Davies
Jan 10, 2013·Experimental Parasitology·Mariza Abreu MirandaJairo Kenupp Bastos
Jan 11, 2011·Travel Medicine and Infectious Disease·Jan Clerinx, Alfons Van Gompel
May 4, 2011·Revista Da Sociedade Brasileira De Medicina Tropical·Caliandra Maria Bezerra Luna LimaMargareth de Fátima Formiga Melo Diniz
Sep 10, 2002·Memórias do Instituto Oswaldo Cruz·Shuhua XiaoMarcel Tanner
Aug 16, 2006·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Sanaa BotrosKarel Masek
May 30, 2019·Infection and Immunity·Achilleas FloudasPadraic G Fallon
Jul 9, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Philip SmithPadraic G Fallon
Oct 30, 2020·Research and Reports in Tropical Medicine·Khalid H AbozeidMohamed M Shohayeb

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