Temporal differences of onset between primary skin lesions and regional lymph node lesions for tularemia in Japan: a clinicopathologic and immunohistochemical study of 19 skin cases and 54 lymph node cases.

Virchows Archiv : an International Journal of Pathology
Shigeyuki AsanoHaruki Wakasa

Abstract

For tularemia, a zoonosis caused by the gram-negative coccobacillus Francisella tularensis, research of the relation between skin lesions and lymph node lesions has not been reported in the literature. This report describes skin lesions and lymph node lesions and their mutual relation over time for tularemia in Japan. Around the second day after infection (DAI), a subcutaneous abscess was observed (abscess form). Hand and finger skin ulcers formed during the second to the fourth week. Subcutaneous and dermal granulomas were observed with adjacent monocytoid B lymphocytes (MBLs) (abscess-granulomatous form). From the sixth week, large granulomas with central homogeneous lesions emerged diffusely (granulomatous form). On 2-14 DAI, F. tularensis antigen in skin lesions was detected in abscesses. During 7-12 DAI, abscesses with adjacent MBLs appeared without epithelioid granuloma (abscess form) in regional lymph nodes. During the second to fifth week, granulomas appeared with necrosis (abscess-granulomatous form). After the sixth week, large granulomas with a central homogeneous lesion (granulomatous form) appeared. F. tularensis antigen in lymph node lesions was observed in the abscess on 7-92 DAI. Apparently, F. tularensis penetr...Continue Reading

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Citations

Dec 3, 2013·Virchows Archiv : an International Journal of Pathology·Shigeyuki AsanoMasaru Kojima
Feb 24, 2015·The American Journal of Dermatopathology·Ana María Molina-RuizLuis Requena
Jun 15, 2013·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Ersin TuncerAysegul Ulu Kilic

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Methods Mentioned

BETA
biopsy

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