Temporal distribution of partial seizures: comparison of an animal model with human partial epilepsy

Annals of Neurology
M QuiggE H Bertram

Abstract

Seizures do not often strike randomly but may occur in circadian patterns. We compared daily times of partial seizures determined by continuous electroencephalography among patients with mesial temporal lobe epilepsy (MTLE; n = 64), those with extratemporal lobe (XTLE; n = 26) or lesional temporal lobe epilepsy (LTLE; n = 8), and a rat model similar to MTLE in which rats become epileptic after electrically induced limbic status epilepticus (postlimbic status [PLS]; n = 20). Rats were maintained on a 12-hour light/dark cycle with lights on at 0700 hours. The distributions of seizures were fitted by cosinor analysis to determine time of peak seizure incidence +/- 95% confidence interval (95% CI). The mean fraction +/- SD of seizures recorded during light was 63 +/- 17% in PLS animals and 60 +/- 21% in humans. Peak incidence of seizures for PLS rats (547 seizures) was 1645 (95% CI = 1448,1830) and for MTLE subjects (774 seizures) was 1500 (95% CI = 1324,1636). Seizures from XTLE (465 seizures) and LTLE (48 seizures) did not fit a cosinor model and occurred no more frequently during light than dark. In conclusion, limbic seizures in humans and PLS rats occur more often during light than dark and have similar cosinor daily distribut...Continue Reading

References

Nov 1, 1991·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·J Gotman
Jan 1, 1990·Annals of Neurology·E H BertramN J Lenn
May 3, 1990·The New England Journal of Medicine·C A CzeislerR E Kronauer
Jan 1, 1989·Electroencephalography and Clinical Neurophysiology·J Gotman, D J Koffler
Jan 1, 1985·Epilepsia·P Kellaway
Jun 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·F K Stephan, I Zucker
Aug 1, 1982·Electroencephalography and Clinical Neurophysiology·C L Ehlers, E K Killam
Aug 28, 1995·Psychiatry Research·H Klemfuss, D F Kripke
Aug 1, 1995·Stroke; a Journal of Cerebral Circulation·M Kelly-HayesR B D'Agostino
Oct 24, 1994·Brain Research·E H Bertram, J F Cornett
Sep 1, 1993·Journal of Neuropathology and Experimental Neurology·D D Armstrong
Oct 1, 1995·European Child & Adolescent Psychiatry·S E Mouridsen
Oct 1, 1996·Stroke; a Journal of Cerebral Circulation·M GalleraniR Manfredini
Jan 1, 1996·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·P J Murphy, S S Campbell
Jan 1, 1996·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·M N ShouseM Sammaritano
Jun 1, 1997·Journal of Biological Rhythms·J D PlautzS A Kay
Feb 1, 1955·Proceedings of the Society for Experimental Biology and Medicine·F HALBERGE L BRACKNEY

❮ Previous
Next ❯

Citations

Oct 12, 2012·Journal of Neurology·Iván Sánchez FernándezTobias Loddenkemper
Feb 14, 2003·Current Neurology and Neuroscience Reports·Carl W Bazil
Mar 5, 2013·Current Neurology and Neuroscience Reports·Sriram RamgopalTobias Loddenkemper
Nov 3, 2011·Neurocritical Care·Richard E TemesMark Quigg
Oct 7, 2003·Epilepsy & Behavior : E&B·Carl W Bazil
Jan 31, 2004·Epilepsy & Behavior : E&B·Milena K PavlovaEdward B Bromfield
Sep 21, 2000·Epilepsy Research·M Quigg
Apr 17, 2003·Epilepsy & Behavior : E&B·L S Stewart, L S Leung
Feb 1, 2006·Brain : a Journal of Neurology·Céline DubéTallie Z Baram
Dec 19, 2002·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Dudley S Dinner
Mar 15, 2011·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Saurabh R Sinha
Mar 15, 2011·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Tobias LoddenkemperSanjeev V Kothare
Feb 13, 2008·Epilepsia·Mark QuiggUNKNOWN NIH Progesterone Trial Study Group
Mar 24, 2011·Epilepsia·Marcin ZarowskiSanjeev V Kothare
Jul 12, 2012·Epilepsia·Magdalena K SmykGilles van Luijtelaar
Jan 17, 2016·Epilepsy & Behavior : E&B·Hipólito NzwaloCarla Bentes
Jan 6, 2016·Epilepsy & Behavior : E&B·Anna Karynna Alves de Alencar RochaDébora Amado
Sep 23, 2014·Epilepsy & Behavior : E&B·Edward H Bertram
May 20, 2015·Epilepsy & Behavior : E&B·Jolien S van CampenKees P J Braun
Jul 21, 2012·Neuroscience·R A B BadawyM J Cook
Feb 22, 2012·Experimental Neurology·Edward H Bertram
Oct 4, 2011·Progress in Neurobiology·Gabriela MatosMonica L Andersen
Mar 29, 2011·Sleep Medicine Reviews·Esther G A van GoldeAl W de Weerd
Jun 15, 2010·Epilepsy Research·Geon Ha KimSeung Bong Hong
Jul 14, 2010·Journal of the Neurological Sciences·Gabriela MatosSergio Tufik
Sep 30, 2009·Epilepsy & Behavior : E&B·Milena K PavlovaEdward B Bromfield
Apr 29, 2009·Sleep Medicine Reviews·Wytske Aelig Hofstra, Al Wytze de Weerd
Jul 1, 2008·Epilepsy & Behavior : E&B·Wytske A Hofstra, Al W de Weerd
Apr 28, 2012·Seizure : the Journal of the British Epilepsy Association·Alexander MirzoevMary Desrocher

❮ Previous
Next ❯

Related Concepts

Related Feeds

Amygdala: Sensory Processes

Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.