PMID: 16646492May 2, 2006Paper

Temporal dynamics of effect concentrations

Environmental Science & Technology
Olga Alda AlvarezJan E Kammenga

Abstract

In effect assessment the comparability and applicability of LCx and ECx values, which are calculated at single points in time during exposure, relies on the ability to perform a valid extrapolation to other time points of interest. The behavior of LCx in time has been extensively studied, and the behavior of ECx in time is expected to follow similar dynamics, as it is considered that the LCx is just a specific case of ECxs. However, most models have focused on validating the dynamics of LCx, and hardly anything is known about the time dependence of ECx for other endpoints or whether it is comparable to that of LCxs. We have created four scenarios where we study the dynamics of the ECx for different endpoints and how it is affected by the characteristics of two different compounds (carbendazim and pentachlorobenzene) and of two different life history strategies (hermaphroditic and sexually reproducing strains of Caenorhabditis elegans). The observed patterns of behavior in time of the ECx for body size and for reproduction showed unexpected dynamics that deviate considerably from that of the LCx. It was demonstrated that the temporal dynamics of ECx were very different for each particular endpoint. The shape of the ECx-time curv...Continue Reading

References

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Citations

Jul 13, 2007·Ecotoxicology·Francisco Sánchez-Bayo, Kouichi Goka
Oct 22, 2008·Ecotoxicology·Tjalling Jager, Sebastiaan A L M Kooijman
Nov 28, 2012·Ecotoxicology·Tjalling JagerVirginie Ducrot
Sep 23, 2009·Ecotoxicology·Tjalling JagerSebastiaan A L M Kooijman
Aug 12, 2014·Ecotoxicology and Environmental Safety·Agnieszka J Bednarska, Justyna Kaszowska
Jun 10, 2015·Ecotoxicology and Environmental Safety·William TyneClaus Svendsen
Dec 9, 2009·The Science of the Total Environment·Jan BaasBas Kooijman
Oct 24, 2009·The Science of the Total Environment·Jan BaasBas Kooijman
May 12, 2007·Ecotoxicology and Environmental Safety·Tjalling JagerDik van de Meent
Apr 9, 2013·Integrated Environmental Assessment and Management·Roman Ashauer, Colin D Brown
Aug 2, 2011·Environmental Toxicology and Chemistry·Roman AshauerThomas G Preuss
Sep 8, 2010·Environmental Toxicology and Chemistry·Lars-Henrik HeckmannTjalling Jager
Aug 4, 2016·Journal of Toxicology and Environmental Health. Part a·Tjalling Jager
Nov 2, 2017·Environmental Science. Processes & Impacts·Roman Ashauer, Tjalling Jager

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