Temporal dynamics of L5 dendrites in medial prefrontal cortex regulate integration versus coincidence detection of afferent inputs

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Nikolai C DembrowDaniel Johnston

Abstract

Distinct brain regions are highly interconnected via long-range projections. How this inter-regional communication occurs depends not only upon which subsets of postsynaptic neurons receive input, but also, and equally importantly, upon what cellular subcompartments the projections target. Neocortical pyramidal neurons receive input onto their apical dendrites. However, physiological characterization of these inputs thus far has been exclusively somatocentric, leaving how the dendrites respond to spatial and temporal patterns of input unexplored. Here we used a combination of optogenetics with multisite electrode recordings to simultaneously measure dendritic and somatic responses to afferent fiber activation in two different populations of layer 5 (L5) pyramidal neurons in the rat medial prefrontal cortex (mPFC). We found that commissural inputs evoked monosynaptic responses in both intratelencephalic (IT) and pyramidal tract (PT) dendrites, whereas monosynaptic hippocampal input primarily targeted IT, but not PT, dendrites. To understand the role of dendritic integration in the processing of long-range inputs, we used dynamic clamp to simulate synaptic currents in the dendrites. IT dendrites functioned as temporal integrators...Continue Reading

Citations

Jun 6, 2015·Cerebral Cortex·Naoki ShigematsuYasuo Kawaguchi
Feb 28, 2018·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Luke Joseph Bogart, Patricio O'Donnell
Feb 15, 2018·Frontiers in Cellular Neuroscience·Andrew S Bohannon, John J Hablitz
Jan 30, 2020·Journal of Neurophysiology·Kevin LeeJohanna M Montgomery
Nov 8, 2017·The Journal of Physiology·Paul G AnastasiadesSimon J B Butt
Apr 27, 2019·Frontiers in Synaptic Neuroscience·Silvana Valtcheva, Laurent Venance
Mar 11, 2021·Journal of Neurophysiology·Craig KelleyWilliam W Lytton
May 12, 2021·Trends in Neurosciences·Paul G Anastasiades, Adam G Carter
May 27, 2021·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Benjamin A HughesA Leslie Morrow
Aug 24, 2021·Frontiers in Cellular Neuroscience·Jonna M Leyrer-JacksonM Foster Olive

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