Temporal dynamics of Puumala hantavirus infection in cyclic populations of bank voles

Scientific Reports
L VoutilainenH Henttonen

Abstract

Understanding the dynamics of zoonotic pathogens in their reservoir host populations is a prerequisite for predicting and preventing human disease epidemics. The human infection risk of Puumala hantavirus (PUUV) is highest in northern Europe, where populations of the rodent host (bank vole, Myodes glareolus) undergo cyclic fluctuations. We conducted a 7-year capture-mark-recapture study to monitor seasonal and multiannual patterns of the PUUV infection rate in bank vole populations exhibiting a 3-year density cycle. Infected bank voles were most abundant in mid-winter months during years of increasing or peak host density. Prevalence of PUUV infection in bank voles exhibited a regular, seasonal pattern reflecting the annual population turnover and accumulation of infections within each year cohort. In autumn, the PUUV transmission rate tracked increasing host abundance, suggesting a density-dependent transmission. However, prevalence of PUUV infection was similar during the increase and peak years of the density cycle despite a twofold difference in host density. This may result from the high proportion of individuals carrying maternal antibodies constraining transmission during the cycle peak years. Our exceptionally intensive...Continue Reading

References

Feb 1, 1980·The Journal of Infectious Diseases·M Brummer-KorvenkontioJ Lähdevirta
Aug 1, 1995·The American Journal of Tropical Medicine and Hygiene·B NiklassonJ Leduc
Dec 29, 1998·Emerging Infectious Diseases·J N Mills, J E Childs
Aug 27, 2002·Emerging Infectious Diseases·Gert E OlssonR Thomas Palo
Nov 1, 2002·The American Journal of Tropical Medicine and Hygiene·John D BooneStephen C St Jeor
Oct 3, 2003·The Lancet Infectious Diseases·Olli VapalahtiAntti Vaheri
Feb 8, 2005·Proceedings. Biological Sciences·Erkki KorpimäkiTero Klemola
Dec 24, 2005·Epidemiology and Infection·H Kallio-KokkoH Henttonen
Jan 19, 2006·Vector Borne and Zoonotic Diseases·S DavisH Leirs
Oct 4, 2006·Proceedings. Biological Sciences·Eva R KallioTapio Mappes
Sep 18, 2007·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·J KochK Stark
Jun 20, 2008·The Journal of Animal Ecology·Pablo M BeldomenicoMichael Begon
Jan 1, 2009·Emerging Infectious Diseases·Gert E OlssonBirger Hörnfeldt
Sep 29, 2009·Trends in Ecology & Evolution·Pablo M Beldomenico, Michael Begon
Mar 20, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Jan ClementMarc van Ranst
Apr 9, 2010·Clinical Microbiology Reviews·Colleen B JonssonOlli Vapalahti
Jul 2, 2010·Proceedings. Biological Sciences·Eva R KallioOlli Vapalahti
Jun 1, 2009·Epidemics·Eva R KallioOlli Vapalahti
Mar 24, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Paul FineDavid L Heymann
Jan 6, 2012·Oecologia·Angela D LuisOttar N Bjørnstad
Jul 5, 2012·Reviews in Medical Virology·Antti VaheriOlli Vapalahti
Feb 15, 2013·PLoS Pathogens·Wen-Ping GuoYong-Zhen Zhang
Oct 31, 2014·Proceedings. Biological Sciences·Katri KorpelaOtso Huitu
May 13, 2015·The Journal of Animal Ecology·Eva R KallioOlli Vapalahti

❮ Previous
Next ❯

Citations

Feb 14, 2017·Journal of Wildlife Diseases·Cristina FevolaHeidi C Hauffe
Jul 17, 2019·EcoHealth·Hussein KhalilBirger Hörnfeldt
Dec 11, 2019·Vector Borne and Zoonotic Diseases·Mónika MadaiFerenc Jakab
Jun 16, 2017·EcoHealth·Joachim MariënHerwig Leirs
Jun 4, 2020·Vector Borne and Zoonotic Diseases·Cristina FevolaHeidi C Hauffe
Dec 7, 2018·Ecology and Evolution·Audrey RohfritschNathalie Charbonnel
Dec 1, 2020·PLoS Neglected Tropical Diseases·Ignacio FerroValeria P Martinez
Jan 26, 2021·Frontiers in Cellular and Infection Microbiology·Won-Keun KimJin-Won Song
Feb 12, 2021·Scientific Reports·Julien HirschingerTimothée Vergne
Aug 29, 2021·Viruses·Antti VaheriJukka Mustonen

❮ Previous
Next ❯

Methods Mentioned

BETA
GAM

Software Mentioned

MatAb
MuMIn package
gamm4
R

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.