Temporal effect of tumor necrosis factor alpha on murine macrophages infected with Mycobacterium avium.

Infection and Immunity
I S Eriks, C L Emerson

Abstract

Members of the Mycobacterium avium complex are a family of bacteria that persist within macrophages in the face of an immune response. Elimination of these organisms is likely due to cytokine-induced macrophage activation. Because macrophage activation by tumor necrosis factor alpha (TNF-alpha) appears critical for killing of intracellular M. avium, early downregulation of TNF-alpha levels in infected macrophages has been suggested as a survival mechanism for virulent strains of M. avium. We examined the relationship between TNF-alpha and growth of M. avium strains of differing virulence, as measured by their ability to grow in murine bone marrow-derived macrophages. When exogenous TNF-alpha was added immediately following macrophage infection, significant growth inhibition of virulent M. avium strains was observed. If TNF-alpha addition was delayed by 24 h or more, growth inhibition was abrogated. To determine if early downregulation of TNF-alpha levels could explain the differential growth of virulent and avirulent strains, levels of TNF-alpha and prostaglandin E2 (PGE2), which has been shown to suppress TNF-alpha production in uninfected macrophages, were quantified over time. Upregulation of both TNF-alpha and PGE2, as meas...Continue Reading

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Citations

Sep 10, 2003·Journal of Leukocyte Biology·Joseph P LopezVirginia L Shepherd
Jun 18, 2014·Journal of Leukocyte Biology·Cynthia H CananJoanne Turner
Feb 27, 2014·The Journal of Clinical Investigation·Roanne KeetonMuazzam Jacobs
Apr 29, 2015·Infectious Diseases·Sheng BiJi-Fang Sheng
Nov 5, 1999·Annual Review of Microbiology·Y Weinrauch, A Zychlinsky
Oct 17, 2002·FEMS Immunology and Medical Microbiology·Jesse M HostetterNorman F Cheville

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