Temporal Efficacy of a Sulforaphane-Based Broccoli Sprout Diet in Prevention of Breast Cancer through Modulation of Epigenetic Mechanisms.

Cancer Prevention Research
Yuanyuan LiTrygve O Tollefsbol

Abstract

Breast cancer is the most common cancer and the second leading cause of cancer-related death among women. An important risk factor for breast cancer is individual genetic background, which is initially generated early in human life, for example, during the processes of embryogenesis and fetal development in utero Bioactive dietary components such as sulforaphane (SFN), an isothiocyanate from cruciferous vegetables including broccoli sprouts (BSp), cabbage, and kale, has been shown to reduce the risk of developing many common cancers through regulation of epigenetic mechanisms. Our study indicates a prenatal/maternal BSp dietary treatment exhibited maximal preventive effects in inhibiting breast cancer development compared with postnatal early-life and adult BSp treatments in two transgenic mouse models that can develop breast cancer. Postnatal early-life BSp treatment starting prior to puberty onset showed protective effects in prevention of breast cancer but was not as effective as the prenatal/maternal BSp treatment. However, adulthood-administered BSp diet did not reduce mammary tumorigenesis. Our results suggest that the prenatal/maternal BSp bioactive natural plant product may impact early embryonic development by regulati...Continue Reading

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Citations

May 18, 2019·Clinical Epigenetics·Shizhao LiTrygve O Tollefsbol
Oct 11, 2019·Cells·Mohammad Mijanur RahmanTrygve O Tollefsbol
Dec 1, 2019·Molecular Cancer Therapeutics·Subrata K PoreShivendra V Singh
Jan 19, 2021·Journal of Oral and Maxillofacial Pathology : JOMFP·D B NandiniPraveen B Reddy
Nov 6, 2020·Seminars in Cancer Biology·Mohammad Fahad UllahFaisel M Abuduhier
Apr 17, 2021·Environmental Science and Pollution Research International·Amr El-SayedMohamed Kamel
Oct 16, 2020·Cancer Prevention Research·Rasika HudlikarAh-Ng Kong
Aug 6, 2021·Journal of Food Biochemistry· Iahtisham-Ul-HaqMuhammad Jawad Iqbal
Jan 5, 2022·Medical Oncology·Priyanka SekarAnanda Vayaravel Cassinadane

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