Oct 31, 2018

Temporal evolution of beta bursts in the parkinsonian cortico-basal ganglia network

BioRxiv : the Preprint Server for Biology
Hayriye CagnanAndrew Sharott

Abstract

Prevalence and temporal dynamics of transient oscillations in the beta frequency band (15-35 Hz), referred to as beta bursts, are correlated with motor performance and tactile perception. Disturbance of these activities is a candidate mechanism for motor impairment in Parkinson's disease (PD), where the excessively long bursts correlate with symptom severity and are reduced by pharmacological and surgical treatments. To date, characterization of beta bursts in PD has been limited to the local field potentials in the subthalamic nucleus (STN) and cortical EEG. Here, we describe the changes that take place in spiking activity across the cortico-basal ganglia circuit, providing a unique insight into the network dynamics of these transient oscillations. Firstly, we demonstrate that rhythmic subthalamic spiking activity emerges at a fixed phase relationship with respect to cortical beta bursts in PD patients. Using multichannel recordings of ensembles of neurons in the 6-OHDA rat model of PD, we then dissect the beta burst dynamics across the sensorimotor cortex and several basal ganglia structures: striatum (Str), globus pallidus externus (GPe) and STN. Each subcortical structure exhibits enhanced rhythmic activity in the beta band...Continue Reading

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Mentioned in this Paper

Biological Neural Networks
Motor Performance
Electroencephalography
Neostriatum
Neurons
Respiratory Burst
Entire Basal Nuclei
Sensorimotor Cortex
Structure of Cortex of Kidney
Subcortical

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