Temporal evolution of left ventricular dyssynchrony after myocardial infarction: relation with changes in left ventricular systolic function

European Heart Journal Cardiovascular Imaging
Gaetano NuciforaVictoria Delgado

Abstract

The relationship between temporal changes in left ventricular (LV) dyssynchrony and LV functional recovery after acute myocardial infarction (MI) remains unclear. Accordingly, the aim of the present study was to evaluate the temporal evolution of LV synchronicity after acute MI, and to explore the relationship between changes in LV systolic function and LV synchronicity. In 193 patients with a first acute MI, LV dyssynchrony (SDI) and global systolic function were evaluated with real-time three-dimensional echocardiography 48 h after percutaneous coronary intervention and at 6 months follow-up. Changes in LV systolic function and synchronicity were evaluated at the follow-up and the relationship between these changes was explored. A total of 59 (40%) patients had an anterior acute MI. Median peak value of troponin T was 2.97 µg/L (1.41-6.06 µg/L). Mean LVEF was 47 ± 8% and mean SDI was 5.01 ± 2.10%, respectively. At 6 months follow-up, a significant improvement in LVEF (50 ± 9 vs. 47 ± 8%; P < 0.001) and SDI (4.52 ± 1.97 vs. 5.01 ± 2.10%; P = 0.003) was noted. A strong correlation was found between LVEF change and SDI change (β = -0.63; P < 0.001). At multivariate analysis, SDI change was an independent factor associated with c...Continue Reading

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Citations

Jun 5, 2013·European Heart Journal Cardiovascular Imaging·Sven PleinPatrizio Lancellotti
Dec 25, 2013·BioMed Research International·Tyler SpataAhmet Kilic
Jul 6, 2013·Pacing and Clinical Electrophysiology : PACE·Georgette E HoogslagVictoria Delgado
Aug 8, 2019·Journal of the American Heart Association·Thomas StiermaierAndreas Schuster

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