PMID: 8960389Aug 1, 1996Paper

Temporal expression of extracellular matrix metalloproteinases and tissue plasminogen activator in the development of collateral vessels in the canine model of coronary occlusion

Canadian Journal of Physiology and Pharmacology
S C TyagiJ L Parker

Abstract

Although heart attack is caused by occlusion of a major coronary artery, some patients have occlusion without heart attack because these patients have sufficient collateral circulation to provide an alternate pathway for blood supply to the myocardium at ischemic risk. The growth of new capillary vessels (angiogenesis) and enlargement of preexisting vessels play an important role in the collateral development. We evaluated the hypothesis that extracellular matrix metalloproteinase (MMP) expression is altered in coronary collateral arteries (0.5-1 mm o.d.) isolated from canine hearts 2-4 months after surgical placement of an ameroid occluder around the proximal left circumflex artery (n = 4), during the development of collateral vessels and restructuring new vessels. Histologic studies (hematoxylin and eosin, trichrome, and van Gieson stains) indicated cellular proliferation and increased collagen and elastin content in collateral vessels compared with comparable-sized unoccluded arterial segments of the left anterior descending (LAD) artery. In situ MMP activity of collateral vessels, measured using denatured collagen in the gel matrix, indicated an increase in total MMP activity in the intima of collateral vessels compared wit...Continue Reading

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Citations

Oct 8, 2005·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Sharad RastogiHani N Sabbah
Feb 13, 2001·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·W LiR Muraoka
May 1, 1998·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·S C Tyagi
Dec 25, 2007·The Journal of Surgical Research·Mark J HobeikaPaul J Gagne
Apr 22, 2004·QJM : Monthly Journal of the Association of Physicians·M H TayebjeeR J MacFadyen

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