Temporal expression of hypoxia-regulated genes is associated with early changes in redox status in irradiated lung.

Free Radical Biology & Medicine
Isabel L JacksonZeljko Vujaskovic

Abstract

The development of normal lung tissue toxicity after radiation exposure results from multiple changes in cell signaling and communication initiated at the time of the ionizing event. The onset of gross pulmonary injury is preceded by tissue hypoxia and chronic oxidative stress. We have previously shown that development of debilitating lung injury can be mitigated or prevented by administration of AEOL10150, a potent catalytic antioxidant, 24h after radiation. This suggests that hypoxia-mediated signaling pathways may play a role in late radiation injury, but the exact mechanism remains unclear. The purpose of this study was to evaluate changes in the temporal expression of hypoxia-associated genes in irradiated mouse lung and determine whether AEOL10150 alters expression of these genes. A focused oligo array was used to establish a hypoxia-associated gene expression signature for lung tissue from sham-irradiated or irradiated mice treated with or without AEOL10150. Results were further verified by RT-PCR. Forty-four genes associated with metabolism, cell growth, apoptosis, inflammation, oxidative stress, and extracellular matrix synthesis were upregulated after radiation. Elevated expression of 31 of these genes was attenuated ...Continue Reading

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Citations

Sep 29, 2015·Radiation Research·Francis N MurigiZeljko Vujaskovic
Jul 17, 2013·Free Radical Biology & Medicine·Brian J Day
Dec 19, 2012·Medical Hypotheses·Samuel R Cohen, Eric P Cohen
Nov 15, 2016·Scientific Reports·Isabel L JacksonZeljko Vujaskovic
Sep 7, 2018·Military Medical Research·Xiao-Rui ZhangYong-Xiang Zhang
May 10, 2020·Health Physics·Evagelia C LaiakisAlbert J Fornace
Feb 27, 2020·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jung Wook HuhMark W Dewhirst
Dec 10, 2020·Environment International·Katalin LumniczkyDörthe Schaue
Nov 16, 2016·Scientific Reports·Isabel L JacksonZeljko Vujaskovic

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