Temporal expression of IL-1beta protein and mRNA in the brain after systemic LPS injection is affected by age and estrogen

Journal of Neuroimmunology
Adam B JohnsonFarida Sohrabji

Abstract

Estrogen has been shown to suppress neural inflammation in vivo in response to intracerebral LPS injections or by intraparenchymal injections of NMDA. Using the latter approach, we have shown that estrogen suppresses inflammatory cytokine expression in lesioned ovariectomized young adult females but not reproductive senescent animals. However, in cultured microglia derived from either young or senescent animals, estrogen fails to suppress LPS-induced cytokine expression. These data suggest that estrogen's effects on the neural inflammatory response may result from its actions on blood-borne immune cells or its actions at the blood brain barrier or both. This hypothesis was directly tested here using a systemic injury model and comparing the neural inflammatory response in the olfactory bulb, which is protected by the blood brain barrier, and in the pituitary gland, which is incompletely protected by the blood brain barrier. Young and senescent Sprague-Dawley female rats were ovariectomized and replaced with either an estrogen or placebo pellet. Three weeks later, animals received a single i.p. injection of LPS (or vehicle) and were terminated 0.5, 2 or 3h later. Systemic injections of LPS increased IL-1beta expression in the li...Continue Reading

References

May 1, 1991·Scandinavian Journal of Immunology·W H KuttehB R Carr
Jan 1, 1988·Neuroscience and Biobehavioral Reviews·B L Hart
Mar 1, 1995·Trends in Neurosciences·N J Rothwell, S J Hopkins
May 1, 1995·Neuroimmunomodulation·W A BanksA J Kastin
Jun 1, 1997·Journal of Biological Rhythms·M WachulecE Satinoff
Nov 11, 1998·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·D B DubalP M Wise
Dec 10, 1999·Neurobiology of Aging·B Hauss-WegrzyniakG L Wenk
Jan 8, 2000·Stroke; a Journal of Cerebral Circulation·N J AlkayedV M Miller
Nov 7, 2000·Journal of Neuroimmunology·P D Drew, J A Chavis
Jan 6, 2001·Endocrinology·D B Dubal, P M Wise
Jan 9, 2001·Brain Research. Molecular Brain Research·M K Jezierski, F Sohrabji
Feb 13, 2001·The Journal of Steroid Biochemistry and Molecular Biology·A MaggiP Ciana
Oct 18, 2002·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·O Z ChiH R Weiss
Feb 21, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Timothy P PlackettElizabeth J Kovacs
Jun 5, 2003·Physiology & Behavior·E D PelosoE Satinoff
Aug 9, 2003·Neuroimmunomodulation·William A BanksJohn E Morley
Mar 24, 2004·Mechanisms of Ageing and Development·Elizabeth J KovacsTimothy P Plackett
May 25, 2004·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·O Z ChiH R Weiss
Nov 13, 2004·JAMA : the Journal of the American Medical Association·Kristine YaffeAnne B Newman
Aug 6, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Alla Y RudayaAndrej A Romanovsky
Oct 8, 2005·Stroke; a Journal of Cerebral Circulation·Daniel RoyJean Raymond
Oct 26, 2005·Neurobiology of Aging·Adam B Johnson, Farida Sohrabji

❮ Previous
Next ❯

Citations

Dec 21, 2006·Nature Reviews. Neuroscience·Michelle L BlockJau-Shyong Hong
Dec 23, 2011·Brain : a Journal of Neurology·Ana I Rodriguez-PerezJose L Labandeira-Garcia
Apr 12, 2012·Endocrinology·Valeria BenedusiAdriana Maggi
May 12, 2009·Frontiers in Neuroendocrinology·Christian J PikeAnna M Barron
Apr 1, 2014·Fertility and Sterility·Barbara FischerSanjay Asthana
Jul 7, 2019·Molecular Neurobiology·Jolie BarterThomas C Foster
Jul 22, 2008·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·James W Simpkins, Meharvan Singh

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Brain Barrier Chips

The blood brain barrier (BBB) is comprised of endothelial cells that regulate the influx and outflux of plasma concentrations. Lab-on-a-chip devices allow scientists to model diseases and mechanisms such as the passage of therapeutic antibodies across the BBB. Discover the latest research on BBB chips here.

Blood Brain Barrier

The blood brain barrier is a border that separates blood from cerebrospinal fluid. Discover the latest search on this highly selective semipermeable membrane here.

Blood Brain Barrier & Cytokines

Some cytokines are able to cross the blood brain barrier through transport systems and enter the cerebrospinal fluid and interstitial fluid spaces. Here is the latest research on cytokines crossing the blood brain barrier and how this can affect tissues within the CNS.