Temporal expression of SOX9 and type II collagen in spheno-occipital synchondrosis of mice after mechanical tension stimuli

The Angle Orthodontist
Teddy CendekiawanA B M Rabie

Abstract

To associate the expressions of SOX9 and type II collagen during growth in the synchondrosis with and without tensile stress in order to understand the role of these factors in the growth of cartilage in spheno-occipital synchondrosis. Sixty 1-day-old male BALB/c mice were randomly divided into experimental and control groups. Each group was subdivided again into five different time points which were 6, 24, 48, 72, and 168 hours. Each subgroup consisted of five mice. Each mouse was sacrificed using an overdose of pentobarbitone sodium. The synchondroses were aseptically removed and incubated in a 24-well plate with or without tensile stress in tissue culture. Tissue sections were stained immunohistochemically to quantitatively analyze the expression of SOX9 and type II collagen. There was a statistically significant increase of 57% (P < .001) in the expression of SOX9 between the experimental and control groups at 24 hours, followed by a significant increase of 44.4% (P < .001) in the expression of type II collagen at 72 hours. SOX9 may play an important role for early differentiation of chondrocytes and increase the expression of type II collagen, a major component of the extracellular matrix, during the growth of cartilage in...Continue Reading

References

Sep 1, 1972·Acta Odontologica Scandinavica·B Ingervall, B Thilander
Nov 29, 1995·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·A J SchaferP N Goodfellow
Apr 1, 1997·Molecular and Cellular Biology·V LefebvreB de Crombrugghe
Jan 10, 2001·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M IkegameH Kawashima
Nov 2, 2002·American Journal of Orthodontics and Dentofacial Orthopedics : Official Publication of the American Association of Orthodontists, Its Constituent Societies, and the American Board of Orthodontics·A B M Rabie, U Hägg
Jan 18, 2003·American Journal of Orthodontics and Dentofacial Orthopedics : Official Publication of the American Association of Orthodontists, Its Constituent Societies, and the American Board of Orthodontics·A B M RabieUrban Hägg
Aug 16, 2003·Bone·D P C RiceI Thesleff
Dec 3, 2004·Frontiers in Bioscience : a Journal and Virtual Library·Hui XiongUrban Hagg
May 13, 2005·Orthodontics & Craniofacial Research·G ShenK Kaluarachchi
Sep 28, 2005·Birth Defects Research. Part C, Embryo Today : Reviews·Véronique Lefebvre, Patrick Smits
Mar 10, 2006·Cell and Tissue Research·Minghui Tang, Jeremy J Mao

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Citations

Nov 5, 2010·Journal of Biomedicine & Biotechnology·Charles WardenHua Zhu
Jul 2, 2010·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·Piero RömerClaudia Reicheneder
Jul 21, 2012·Orthodontics & Craniofacial Research·N KatebiB R Olsen
Dec 31, 2014·Cranio : the Journal of Craniomandibular Practice·Gennaro Castaldo, Francesco Cerritelli
Mar 6, 2012·Archives of Oral Biology·Piero RömerPeter Proff

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