Temporal Expression Patterns of Genes Related to Sex Steroid Action in Sexually Dimorphic Nuclei During Puberty

Frontiers in Endocrinology
Moeko KanayaShinji Tsukahara

Abstract

Sex steroids play a major role in sexually dimorphic brain development during not only the perinatal period but also the pubertal period. We previously showed that, in male mice, the estrogen receptor-α (Esr1) and aromatase (Cyp19a1) genes are essential to the sexually dimorphic formation of the anteroventral periventricular nucleus (AVPV) and the principal nucleus of the bed nucleus of the stria terminalis (BNSTp), but the estrogen receptor-β (Esr2) gene is not necessary. We also showed that the androgen receptor (Ar) gene is essential to the sexually dimorphic formation of the BNSTp. These genes are expressed in the AVPV and BNSTp of perinatal mice. However, it remains unknown whether these genes are expressed in the AVPV and BNSTp during puberty, and whether the expression, if any, differs by sex, age, and brain region. Here, we dissected the AVPV and BNSTp from Nissl-stained brain sections of male and female mice on postnatal day (PD) 20 (prepuberty), PD30 (puberty onset in females), PD40 (puberty onset in males), and PD60 (young adult) using a laser microdissection system. We then examined the mRNA levels of Esr1, Esr2, Cyp19a1, and Ar in these brain regions. In the AVPV, Esr1 mRNA levels were greater in females than males...Continue Reading

References

Jul 1, 1991·The Journal of Endocrinology·M A Mannan, P J O'Shaughnessy
Jul 1, 1990·Journal of Neurobiology·G J De Vries, H A al-Shamma
Feb 1, 1994·Journal of Neuroendocrinology·C W Malsbury, K McKay
Aug 4, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Alexandre V PatchevWolfgang Rohde
Sep 3, 2004·Proceedings of the National Academy of Sciences of the United States of America·Nancy G ForgerGeert J de Vries
Jun 24, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jeremy T SmithRobert A Steiner
Jan 6, 2007·Endocrinology·Alexander S KauffmanManuel Tena-Sempere
Dec 7, 2007·Progress in Neurobiology·Heather K CaldwellW Scott Young
Jan 23, 2009·Nature Neuroscience·Eman I AhmedCheryl L Sisk
Feb 12, 2009·Journal of Neuroendocrinology·N G Forger
Dec 15, 2012·The Journal of Comparative Neurology·Benjamin D RoodGeert J De Vries
Sep 4, 2013·Hormones and Behavior·Janice M JuraskaLydia L DonCarlos

❮ Previous
Next ❯

Citations

Oct 31, 2018·Frontiers in Molecular Neuroscience·Dusti A ShayCheryl S Rosenfeld

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR
ESR

Software Mentioned

Stereo Investigator
Power
SPSS Statistics

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.