Temporal expression profiles of organic anion transport proteins in placenta and fetal liver of the rat

American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
M V St-PierreP J Meier

Abstract

Physiological cholestasis linked to immature hepatobiliary transport systems for organic anions occurs in rat and human neonates. In utero, the placenta facilitates vectorial transfer of certain fetal-derived solutes to the maternal circulation for elimination. We compared the ontogenesis of organic anion transporters in the placenta and the fetal liver of the rat to assess their relative abundance throughout gestation and to determine whether the placenta compensates for the late maturation of transporters in the developing liver. The mRNA of members of the organic anion transporting polypeptide (Oatp) superfamily, the multidrug resistance protein (Mrp) family, one organic anion transporter (OAT), and the bile acid carriers Na(+)-taurocholate cotransporting polypeptide (Ntcp) and bile salt export pump (Bsep) was quantified by real-time PCR. The most abundant placental transporters were Oatp4a1, whose mRNA increased 10-fold during gestation, and Mrp1. Mrp1 immunolocalized predominantly to epithelial cells of the endoplacental yolk sac, suggesting an excretory role that sequesters fetal-derived solutes in the yolk sac cavity, and faintly to the basal syncytiotrophoblast surface. The mRNA levels of Oatp2b1, Mrp3, and Bsep in the ...Continue Reading

References

May 1, 1979·The Journal of Clinical Investigation·J M LittleR Lester
Jan 1, 1992·Annual Review of Cell Biology·C F Higgins
Dec 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·B HagenbuchP J Meier
May 23, 1998·The Journal of Biological Chemistry·T GerloffP J Meier
Sep 9, 1998·The American Journal of Physiology·R H AngelettiA W Wolkoff
Oct 2, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M MassimiS K Erickson
Sep 2, 1999·Advances in Enzyme Regulation·D KepplerA Nies
Jan 25, 2000·The Journal of Biological Chemistry·T HirohashiY Sugiyama
Feb 29, 2000·Molecular Pharmacology·J MadonB Stieger
Mar 11, 2000·American Journal of Physiology. Gastrointestinal and Liver Physiology·K OgawaY Sugiyama
Mar 25, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R I MaciasJ J Marin
Apr 6, 2000·American Journal of Physiology. Renal Physiology·A PavlovaS K Nigam
Aug 17, 2000·Journal of the National Cancer Institute·P BorstJ Wijnholds
Sep 27, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·M V St-PierreJ J Marin
Nov 15, 2000·Seminars in Liver Disease·D Keppler, J König
Nov 30, 2000·American Journal of Physiology. Gastrointestinal and Liver Physiology·H C WaltersP A Dawson
Feb 13, 2001·Molecular and Cellular Endocrinology·H MasuyamaT Kudo
Apr 3, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·C J SorokaJ L Boyer
Feb 12, 2002·Pharmaceutical Research·Hidetaka AkitaYuichi Sugiyama
Feb 14, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·Vadim S ZinchukHarumichi Seguchi
Feb 21, 2002·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Grace L GuoCurtis D Klaassen
Apr 5, 2002·The Journal of Clinical Endocrinology and Metabolism·M V St-PierreT Stallmach
May 15, 2002·American Journal of Physiology. Endocrinology and Metabolism·Yasumasa GotohYuichi Sugiyama
May 16, 2002·Toxicological Sciences : an Official Journal of the Society of Toxicology·David R Johnson, Curtis D Klaassen
Jul 19, 2002·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Hao XiongMasahiko Negishi
Oct 31, 2002·Gastroenterology·Johannes NoéPeter J Meier
Jan 2, 2003·Proceedings of the National Academy of Sciences of the United States of America·Bryan GoodwinJoyce J Repa
Jan 16, 2003·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Tyra M Leazer, Curtis D Klaassen

❮ Previous
Next ❯

Citations

Jan 23, 2013·European Journal of Drug Metabolism and Pharmacokinetics·Yan ZhouXin-An Wu
Jun 21, 2008·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Lauren M AleksunesCurtis D Klaassen
Jan 28, 2010·Pharmacological Reviews·Curtis D Klaassen, Lauren M Aleksunes
Apr 13, 2010·Environmental Health Perspectives·Miyu NishikawaHiroshi Yokota
Dec 11, 2013·International Journal of Molecular Sciences·Jamie E Moscovitz, Lauren M Aleksunes
Feb 21, 2009·World Journal of Gastroenterology : WJG·Rocio I R MaciasMaria A Serrano
Jan 26, 2011·European Journal of Histochemistry : EJH·E LacunzaM V Croce
Sep 30, 2009·Expert Opinion on Drug Metabolism & Toxicology·Päivi MyllynenKirsi Vähäkangas
Nov 20, 2012·Molecular and Cellular Endocrinology·Shadi Abu-HayyehCatherine Williamson
Sep 28, 2010·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Caroline MacLeanGert Fricker
Mar 20, 2009·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Elisabeth SölderPaul L Debbage
Mar 15, 2008·Liver International : Official Journal of the International Association for the Study of the Liver·Jose J G MarinMaria A Serrano
Oct 10, 2013·BioFactors·Katrin Wlcek, Bruno Stieger
Mar 26, 2015·Journal of the American Society for Mass Spectrometry·M Reid GrosecloseStephen Castellino
Sep 24, 2014·Reproductive Toxicology·Romina HigaAlicia Jawerbaum
Mar 3, 2015·Basic & Clinical Pharmacology & Toxicology·Barent DuBoisSonnet S Jonker
Jun 20, 2015·Clinical Pharmacology and Therapeutics·K L R BrouwerUNKNOWN Pediatric Transporter Working Group
Oct 30, 2007·Drug Metabolism and Pharmacokinetics·Makoto ChibaKen Iseki
May 17, 2017·Molecular Aspects of Medicine·Saraid McIlvrideCatherine Williamson
Dec 26, 2006·Pflügers Archiv : European journal of physiology·Eva Bakos, László Homolya
Feb 1, 2019·Parasite Immunology·Najwa NajjarMicheline Piquette-Miller
Nov 5, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Oscar BrizJose J G Marin
May 29, 2008·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Vanja PetrovicMicheline Piquette-Miller
Nov 4, 2016·Pharmaceutical Research·Anand A JoshiPhillip M Gerk
Sep 24, 2005·Experimental Biology and Medicine·Charles E WoodMaureen Keller-Wood
Apr 20, 2019·Frontiers in Endocrinology·Barbara K Stepien, Wieland B Huttner

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.