Temporal genetic diversity of Schistosoma japonicum in two endemic sites in China revealed by microsatellite markers

Parasites & Vectors
Ming-Bo YinWei Hu

Abstract

Schistosomiasis is one of the neglected tropical diseases. The causative agent of schistosomiasis in China, Schistosoma japonicum, has long been a major public health problem. An understanding of fundamental evolutionary and genetic processes in this species has major implications for its control and elimination. Intensive control efforts have greatly reduced the incidence of schistosomiasis in China, but little is known about the genetic consequences of these efforts. To investigate this, we sampled twice (years 2003 and 2011) from two endemic regions where populations of S. japonicum had persisted despite control efforts and genotyped these samples using ten microsatellite markers. Our main hypothesis was that parasite genetic diversity would be greatly reduced across this time period. There was no apparent reduction in allelic diversity, and a non-significant reduction in clonal diversity in these parasite populations between 2003 and 2011. We did, however, detect temporal genetic differentiation among the samples. Such a significant temporal genetic variation of S. japonicum populations has not been reported before.

References

Jan 1, 1997·International Journal for Parasitology·D RollinsonM Tanaka
Oct 2, 2009·Tropical Medicine & International Health : TM & IH·Long-De WangXiao-Nong Zhou
Feb 22, 2012·PLoS Neglected Tropical Diseases·Qin Ping ZhaoPin Nie
Jan 1, 2012·Infectious Diseases of Poverty·Charles CollinsShenglan Tang

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Methods Mentioned

BETA
PCR
PCRs
electrophoresis

Software Mentioned

Arlequin
FSTAT
GenAlEx
GeneMapper

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