Temporal hemodynamic changes in a female mouse model of systemic lupus erythematosus.

American Journal of Physiology. Renal Physiology
Elena L DentMichael J Ryan

Abstract

Systemic lupus erythematosus (SLE) is a chronic multisystem autoimmune disease characterized by circulating autoantibodies, prevalent hypertension, renal injury, and cardiovascular disease. Onset of the disease often occurs in young women of childbearing age. Although kidney involvement is common to patients with SLE, little is known about temporal changes in renal hemodynamic function and its relationship to the pathogenesis of hypertension during autoimmune diseases. We hypothesized that the loss of immunological tolerance and subsequent production of autoantibodies in SLE leads to impaired renal hemodynamic function that precedes the development hypertension. Female NZBWF1 (SLE) mice and female NZW/LacJ (control) mice were instrumented with carotid artery and jugular vein catheters to determine mean arterial pressure (MAP) and glomerular filtration rate, respectively, at ages of 15, 20, 24, 28, 31, and 34 wk. In addition, urinary albumin excretion, blood urea nitrogen, circulating autoantibodies, and glomerulosclerosis were assessed at each age. Levels of circulating autoantibodies are increased between 24 and 28 wk of age in NZBWF1 mice and were significantly greater than in control mice. Glomerular filtration rate was sign...Continue Reading

References

Nov 1, 1978·The Journal of Experimental Medicine·B S AndrewsF J Dixon
Feb 1, 1976·The American Journal of Medicine·M B UrowitzM A Ogryzlo
Jan 1, 1973·Seminars in Arthritis and Rheumatism·M Siegel, S L Lee
Jun 1, 1997·Annals of the Rheumatic Diseases·E Batlle-GualdaE Pascual
Aug 26, 1998·Annals of the Rheumatic Diseases·M NakanoM Arakawa
Dec 16, 1998·International Journal of Immunopharmacology·Y W SongK M Hong
Nov 13, 1999·Arteriosclerosis, Thrombosis, and Vascular Biology·P M SchwarzU Förstermann
Sep 1, 2000·American Journal of Physiology. Renal Physiology·R KomersS Anderson
Oct 17, 2003·The New England Journal of Medicine·Melissa R ArbuckleJohn B Harley
Dec 8, 2004·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Roger BurnettJacques Descotes
Mar 2, 2005·Circulation·Thomas J WangRamachandran S Vasan
Jul 27, 2006·Acta Physiologica·P F Mount, D A Power
Aug 5, 2006·The American Journal of Medicine·Andrea DoriaSilvano Todesco
Sep 15, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Michael J Ryan, Gerald R McLemore
Oct 21, 2006·Journal of the American Academy of Dermatology·Andrea L NeimannJoel M Gelfand
Nov 14, 2007·Circulation·Mary J Roman, Jane E Salmon
Jun 27, 2008·Journal of the American Society of Nephrology : JASN·John P FormanGary C Curhan
Dec 17, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Cheryl SmithChris Baylis
Jan 13, 2009·Seminars in Arthritis and Rheumatism·Guillermo J Pons-EstelGlinda S Cooper
Feb 6, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Marcia Venegas-PontMichael J Ryan
Jan 12, 2010·Clinical Reviews in Allergy & Immunology·Corinna E Weckerle, Timothy B Niewold
Jan 20, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Manuela Frese-SchaperSteffen Frese
Jan 12, 2011·Renal Failure·Monica G Arellano-MendozaBruno Escalante
Mar 16, 2011·Journal of Biomedicine & Biotechnology·Daniel PerryLaurence Morel
Mar 17, 2011·The Journal of Rheumatology·José Mario SabioUNKNOWN Grupo Lupus Virgen de las Nieves
Sep 6, 2011·European Heart Journal·Ulrich Förstermann, William C Sessa
Sep 9, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Marcia Venegas-PontMichael J Ryan
Sep 16, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Keisa W MathisMichael J Ryan
Nov 15, 2011·Arthritis Research & Therapy·Ramesh SaxenaChandra Mohan
Jul 5, 2012·Clinical & Developmental Immunology·Susan Yung, Tak Mao Chan
Jul 28, 2012·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Paul A SminkDick de Zeeuw
Mar 2, 2013·Arthritis Research & Therapy·Hans-Joachim Anders, Jan J Weening
Jul 13, 2013·Current Opinion in Rheumatology·Jason S Knight, Mariana J Kaplan
Aug 9, 2013·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Keisa W MathisMichael J Ryan
Aug 21, 2013·Seminars in Arthritis and Rheumatism·Konstantinos TseliosDafna D Gladman
Nov 16, 2013·Autoimmunity·Johanna T Gustafsson, Elisabet Svenungsson

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Citations

May 7, 2020·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Gina L C Yosten
Sep 18, 2021·Clinical Science·Erika I Boesen, Rahul M Kakalij

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Methods Mentioned

BETA
ELISA
flow cytometry

Software Mentioned

Bio
GraphPad
Rad ImageLab
GraphPad Prism

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