Temporal integrity of an airborne odor stimulus is greatly affected by physical aspects of the odor delivery system

Chemical Senses
Richard S VetterC Giovanni Galizia

Abstract

There is currently a debate about the role played by temporal patterns in neural activity in olfactory coding. An accurate analysis of this question, however, is only possible if the temporal properties of a stimulus itself are well defined. So far, no technique with sufficient temporal resolution has been available to accomplish this. Using a photoionization detector (PID), we show that the configuration of the odor delivery apparatus and the airflow settings greatly influence the integrity of a stimulus profile within an odor delivery apparatus. In a situation where pulsatile odor stimuli are applied to a stationary preparation, we tested the effect of 1) axial and off-center location within the airstream, 2) airflow of the odor delivery, 3) exit tube length, 4) exit tube diameter, 5) orientation of the odor delivery device in relation to the exhaust flow, and 6) exhaust tube air speed. This has important implications for the study of time in olfaction; significant planning must be incorporated into the design of the experiment to provide a well-defined odor delivery system.

References

Dec 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·T C BakerJ Löfqvist
Oct 1, 1993·Journal of Comparative Physiology. A, Sensory, Neural, and Behavioral Physiology·T A ChristensenJ G Hildebrand
May 1, 1996·Journal of Neurobiology·T A ChristensenJ G Hildebrand
Mar 22, 2001·Nature·N J VickersJ G Hildebrand

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Citations

Nov 16, 2011·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Anneke Meyer, C Giovanni Galizia
Mar 9, 2011·Proceedings of the National Academy of Sciences of the United States of America·Chih-Ying SuJohn R Carlson
Apr 14, 2009·Chemical Senses·Koutaroh Okada, Masayuki Sakuma
Mar 1, 2012·Chemical Senses·Martin N AnderssonTeun Dekker
Sep 21, 2007·Chemistry Central Journal·Michael SchmukerGisbert Schneider
May 5, 2012·PloS One·Paul SzyszkaC Giovanni Galizia
Apr 12, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Carlotta MartelliThierry Emonet
Apr 9, 2008·Journal of Neuroscience Methods·Julia Schuckel, Andrew S French
Jul 11, 2006·Current Opinion in Neurobiology·Zachary F Mainen
Oct 12, 2010·Journal of Neuroscience Methods·Shannon B OlssonBill S Hansson
Jan 13, 2015·Nature Neuroscience·Priyanka GuptaUpinder S Bhalla
Sep 16, 2016·Scientific Reports·Li-Jie JiaYan Xu
Mar 4, 2017·Arthropod Structure & Development·Noriyasu Ando, Ryohei Kanzaki
Dec 25, 2007·Nature Neuroscience·Matthieu LouisLeslie B Vosshall
Jul 19, 2011·Nature Neuroscience·Roman ShustermanDmitry Rinberg
Mar 20, 2020·Archives of Insect Biochemistry and Physiology·Giulia CordaGiorgia Sollai
Dec 13, 2019·Frontiers in Physiology·Mario Pannunzi, Thomas Nowotny
Aug 26, 2011·The Journal of Experimental Biology·Matthew A Reidenbach, M A R Koehl
Jul 5, 2011·Cold Spring Harbor Protocols·Richard Benton, Anupama Dahanukar

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