Temporal lobe epilepsy surgery: outcome, complications, and late mortality rate in 215 patients

Epilepsia
V SalanovaR Worth

Abstract

We studied the surgical outcome, complications, and the late mortality rate in a large group of patients with medically refractory temporal lobe epilepsy (TLE). Two-hundred fifteen patients with TLE were treated surgically between 1984 and 1999 after a comprehensive presurgical evaluation. Patients were followed up at 6 weeks, 3-6 months, and yearly thereafter. In addition, questionnaires were sent on the anniversary of their surgery. Surgical outcome (Engel's classification), complication rate, and factors contributing to late mortality were analyzed. Standardized mortality ratios (SMRs) were calculated. There was no surgical mortality. Two (0.9%) had mild hemiparesis, one (0.4%) had a hemianopia, seven (3.2%) had transient cranial nerve palsies, and eight (3.7%) had transient postoperative language difficulties. One hundred forty-eight (69%) became seizure free, 43 (20%) had rare seizures, 14 (6.5%) had worthwhile seizure reduction, and 10 (4.6%) had no improvement (follow-up, 1-15 years). Three (2%) of 148 seizure-free patients died during follow-up, compared with eight (11.9%) of 67 not seizure-free patients. The mean duration of epilepsy before surgery for the surviving patients was 17.8 years, and for those patients who d...Continue Reading

References

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Citations

Jun 26, 2004·Current Neurology and Neuroscience Reports·Samuel Wiebe
May 7, 2010·Current Neurology and Neuroscience Reports·Maromi Nei, Ryan Hays
Jun 27, 2008·Current Treatment Options in Neurology·José F Téllez-Zenteno, Samuel Wiebe
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