PMID: 9557667Apr 29, 1998Paper

Temporal mapping of transcripts in herpesvirus 6 variants

Journal of Virology
P MirandolaD Di Luca

Abstract

To define the molecular features characteristic of the early stages of infection of lymphocytes with human herpesvirus 6 (HHV-6) variant A or B, we studied the temporal regulation of expression of selected sets of viral genes. Thus, U42, U94, U89-U90, U73, and U39 are alpha genes since their transcripts (i) were made in the presence of inhibitors of protein synthesis and (ii) were detected 3 h after infection of untreated cells. U41, U53, U31, and U19 are beta genes since their expression is inhibited by cycloheximide but not by phosphonoacetate, an inhibitor of DNA synthesis. U100 is a gamma gene since its spliced transcript encoding the structural glycoprotein gp82/105 was first detected 16 h after infection of untreated cells but could not be detected in cells treated with phosphonoacetate. HHV-6 variants differ in the transcription patterns of their genes. U16-U17 originates a splice transcript and is regulated as alpha in HHV-6B and as beta in HHV-6A. U91 generates two transcripts, amplified as 476- and 374-bp PCR fragments. The 476-bp fragment is alpha in HHV-6A-infected cells but beta in HHV-6B-infected cells. Conversely, the 374-bp fragment is beta in HHV-6A-infected cells and alpha in HHV-6B-infected cells. Furthermore...Continue Reading

References

May 28, 1992·The New England Journal of Medicine·P PruksananondaT R Dambaugh
Jun 1, 1992·The Journal of Pediatrics·P J PreziosoM A Greco
Dec 1, 1992·Archives of Disease in Childhood·Y AsanoT Kurata
Jun 1, 1991·The Journal of General Virology·K KondoK Yamanishi
Jul 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·E C SchirmerN Frenkel
Jan 1, 1990·Journal of Virology·G L LawrenceB G Barrell
Mar 1, 1990·Transplantation·T OkunoK Tanaka
Oct 1, 1990·The Journal of Infectious Diseases·L S WyattN Frenkel
Jul 1, 1989·Journal of Virology·K TakahashiK Yamanishi
Nov 1, 1989·Journal of Virological Methods·J B BlackP E Pellett
Aug 15, 1987·Lancet·R G DowningB E Griffin
Feb 1, 1995·Immunology Today·P Lusso, R C Gallo
Jul 15, 1993·The New England Journal of Medicine·R W ConeL Corey
Jun 15, 1996·Annals of Internal Medicine·N Singh, D R Carrigan

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Citations

Nov 13, 1998·Proceedings of the National Academy of Sciences of the United States of America·A RotolaD Di Luca
May 27, 2003·Journal of Medical Virology·Hiroki IsomuraMasao Yamada
Jun 6, 2007·Multiple Sclerosis : Clinical and Laboratory Research·Roverto Alvarez-LafuenteRafael Arroyo
Jul 22, 2010·Journal of Medical Virology·Louis FlamandDharam V Ablashi
May 5, 2017·Journal of Virology·Annie GravelLouis Flamand
Jul 5, 2002·Journal of Virology·Bodil Øster, Per Höllsberg
Oct 22, 2002·The Journal of General Virology·Richard StantonGavin W G Wilkinson
Oct 14, 2003·Journal of Medical Virology·Richard StantonJulie D Fox
May 13, 2003·Reviews in Medical Virology·Zhi-Ming Zheng
Jan 18, 2005·Clinical Microbiology Reviews·Leen De BolleErik De Clercq
May 27, 2003·Journal of Medical Virology·Arnaldo CarusoSimona Fiorentini
Aug 26, 2004·Multiple Sclerosis : Clinical and Laboratory Research·A RotolaE Cassai
Jul 25, 2012·Journal of Medical Virology·Masaru IhiraTetsushi Yoshikawa
Nov 7, 2013·Archives of Virology·Dharam AblashiTetsushi Yoshikawa
May 26, 1999·Emerging Infectious Diseases·G Campadelli-FiumeL Menotti
Mar 13, 2003·Journal of Clinical Periodontology·Enrico CassaiAntonella Rotola
Dec 19, 2002·Journal of Medical Microbiology·D H Dockrell
Nov 26, 1999·The Journal of General Virology·P MenegazziD Di Luca
Jul 25, 2009·The Journal of General Virology·Edward H TsaoDuncan A Clark
Nov 16, 2004·Journal of Medical Virology·N NishimuraT Iwasaki
Apr 15, 2006·Brain Pathology·Roberto Alvarez-LafuenteRafael Arroyo
May 15, 2020·Brain Sciences·Santa Rasa-DzelzkalejaModra Murovska
Mar 22, 2002·Journal of Virology·Kazuhiro KondoKoichi Yamanishi
Sep 11, 1999·Journal of Virology·Y IsegawaK Yamanishi
Mar 7, 2020·Frontiers in Microbiology·Daria BortolottiRoberta Rizzo
May 18, 2000·Reviews in Medical Virology·D A Clark
Oct 19, 1999·Journal of Clinical Microbiology·R A NortonS Dewhurst
May 29, 2001·Journal of Clinical Microbiology·G Van den BoschZ N Berneman

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