Temporal muscle thickness is an independent prognostic marker in melanoma patients with newly diagnosed brain metastases

Journal of Neuro-oncology
Julia FurtnerMatthias Preusser

Abstract

The purpose of this study was to evaluate the prognostic relevance of temporal muscle thickness (TMT) in melanoma patients with newly diagnosed brain metastases. TMT was retrospectively assessed in 146 melanoma patients with newly diagnosed brain metastases on cranial magnetic resonance images. Chart review was used to retrieve clinical parameters, including disease-specific graded prognostic assessment (DS-GPA) and survival times. Patients with a TMT > median showed a statistically significant increase in survival time (13 months) compared to patients with a TMT < median (5 months; p < 0.001; log rank test). A Cox regression model revealed that the risk of death was increased by 27.9% with every millimeter reduction in TMT. In the multivariate analysis, TMT (HR 0.724; 95% 0.642-0.816; < 0.001) and DS-GPA (HR 1.214; 95% CI 1.023-1.439; p = 0.026) showed a statistically significant correlation with overall survival. TMT is an independent predictor of survival in melanoma patients with brain metastases. This parameter may aid in patient selection for clinical trials or to the choice of different treatment options based on the determination of frail patient populations.

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Citations

Sep 16, 2020·Journal of Cancer Research and Clinical Oncology·Geon AnYong- Kil Hong
Aug 8, 2020·Asia-Pacific Journal of Clinical Oncology·Havva Yesil Cinkir, Hale Colakoglu Er
Feb 25, 2021·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Hidetaka OnoderaYohtaro Sakakibara
Mar 24, 2021·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Seok Jong ChungPhil Hyu Lee
Jun 6, 2021·Archives of Gerontology and Geriatrics·Katsuhiko SakaiNobuyuki Matsuura
Jun 30, 2021·Clinical Neurology and Neurosurgery·Sakibul HuqDebraj Mukherjee
Oct 21, 2021·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Julia FurtnerUNKNOWN EORTC Brain Tumor Group

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