Temporal Neuromodulation of Retinal Ganglion Cells by Low-Frequency Focused Ultrasound Stimulation

IEEE Transactions on Neural Systems and Rehabilitation Engineering : a Publication of the IEEE Engineering in Medicine and Biology Society
Qiuju JiangHairong Zheng

Abstract

Significant progress has been made recently in treating neurological blindness using implantable visual prostheses. However, implantable medical devices are highly invasive and subject to many safety, efficacy, and cost issues. The discovery that ultrasound (US) may be useful as a noninvasive neuromodulation tool has aroused great interest in the field of acoustic retinal prostheses (ARPs). We have investigated the responsiveness of rat retinal ganglion cells (RGCs) to low-frequency focused US stimulation (LFUS) at 2.25 MHz and characterized the neurophysiological properties of US responses by performing in vitro multielectrode array recordings. The results show that LFUS can reliably activate RGCs. The US-induced responses did not correspond to the standard light responses and varied greatly among cell types. Moreover, dual-peak responses to US stimulation were observed that have not been reported previously. The temporal response properties of RGCs, including their latency, firing rate, and response type, were modulated by the acoustic intensity. These findings suggest the presence of a temporal neuromodulation effect of LFUS and potentially open a new avenue in the development of ARP.

References

Jul 15, 1974·Experientia·D I Hamasaki, R W Winters
Sep 1, 1971·The Journal of Physiology·B G ClelandW R Levick
Jan 9, 1999·The Journal of Biological Chemistry·F MaingretE Honoré
May 1, 1952·Journal of Experimental Psychology·P G CHEATHAM
Feb 6, 2007·Brain Research·Yi ZhouPei-Ji Liang
Aug 21, 2007·Journal of Biomaterials Science. Polymer Edition·Jessica O WinterJoseph F Rizzo
Jun 16, 2010·Neuron·Yusuf TufailWilliam J Tyler
Mar 1, 2011·NeuroImage·Seung-Schik YooFerenc A Jolesz
Mar 8, 2011·BMC Neuroscience·Byoung-Kyong MinSeung-Schik Yoo
May 18, 2011·Clinical & Experimental Ophthalmology·Jong Min Ong, Lyndon da Cruz
Sep 3, 2011·Nature Protocols·Yusuf TufailWilliam J Tyler
Dec 8, 2011·Expert Review of Medical Devices·Thomas GuentherGregg J Suaning
Dec 12, 2012·Ultrasound in Medicine & Biology·Randy L KingKim Butts Pauly
Mar 8, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Michael D MenzStephen A Baccus
Nov 19, 2013·Current Biology : CB·Thomas DeffieuxJean-François Aubry
Mar 20, 2014·Ultrasound in Medicine & Biology·Randy L KingKim Butts Pauly
Apr 9, 2014·IEEE Transactions on Bio-medical Engineering·James D Weiland, Mark S Humayun
Oct 1, 2014·Brain Stimulation·Jerel MuellerWilliam J Tyler
Apr 27, 2016·Scientific Reports·Jan KubanekJianmin Cui
Mar 23, 2017·IEEE Transactions on Neural Systems and Rehabilitation Engineering : a Publication of the IEEE Engineering in Medicine and Biology Society·Mengdi GaoHairong Zheng

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Citations

May 28, 2020·Micromachines·Shinyong ShimSung June Kim
Oct 18, 2020·Micromachines·Pei-An LoLan Yue
May 14, 2021·Journal of Neural Engineering·Sai Siva KareLaxman Saggere

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