Temporal parameters of post-stress prophylactic glucose treatment in rats

Stress : the International Journal on the Biology of Stress
M A ConoscentiT R Minor

Abstract

Acute trauma can lead to life-long changes in susceptibility to psychiatric disease, such as post-traumatic stress disorder (PTSD). Rats given free access to a concentrated glucose solution for 24 h beginning immediately after trauma failed to show stress-related pathology in the learned helplessness model of PTSD and comorbid major depression. We assessed effective dosing and temporal constraints of the glucose intervention in three experiments. We exposed 120 male Sprague-Dawley rats to 100, 1 mA, 3-15 s, inescapable and unpredictable electric tail shocks (over a 110-min period) or simple restraint in the learned helplessness procedure. Rats in each stress condition had access to a 40% glucose solution or water. We measured fluid consumption under 18-h free access conditions, or limited access (1, 3, 6, 18 h) beginning immediately after trauma, or 3-h access with delayed availability of the glucose solution (0, 1, 3, 6 h). We hypothesized that longer and earlier access following acute stress would improve shuttle-escape performance. Rats exposed to traumatic shock and given 18-h access to glucose failed to show exaggerated fearfulness and showed normal reactivity to foot shock during testing as compared to their water-treated...Continue Reading

References

Jan 1, 1991·Neuroscience and Biobehavioral Reviews·R M Zacharko, H Anisman
Jul 1, 1990·Neuroendocrinology·H C HornerR M Sapolsky
Feb 15, 1988·Biological Psychiatry·J L HaraczE G Zimmermann
Jan 1, 1972·Ciba Foundation Symposium·G L Engel, A H Schmale
Apr 1, 1995·Current Opinion in Neurobiology·B S McEwen, R M Sapolsky
Feb 1, 1995·Physiology & Behavior·G J KantP S Covington
Jan 1, 1994·Annals of Neurology·L L Dugan, D W Choi
Oct 24, 2000·Neurobiology of Disease·R M Sapolsky
Mar 8, 2003·Neuroendocrinology·Madhuri Roy, Robert M Sapolsky
Apr 1, 2004·Learning & Memory·Tracey J Shors
Sep 1, 2004·Neuropeptides·Markus Heilig
Nov 10, 2013·Biological Psychiatry·Daniel E GlennMichelle G Craske
Oct 17, 2014·Stress : the International Journal on the Biology of Stress·Traci N PlumbThomas R Minor

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Citations

Jun 4, 2019·Frontiers in Behavioral Neuroscience·Michael A Conoscenti, Michael S Fanselow
Jun 12, 2021·Stress : the International Journal on the Biology of Stress·Traci N PlumbMichael S Fanselow

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