Temporal pattern formation by heterochronic genes

Annual Review of Genetics
F Slack, G Ruvkun

Abstract

Heterochrony describes the phylogenetic variation in the relative timing of major developmental events. Such heterochronic variation has been noted across phylogeny, including closely related species, suggesting that particular genetic loci control global aspects of developmental timing, and that variation at those loci may play important roles in evolutionary change. Genetic analyses of heterochronic mutations in the nematode Caenorhabditis elegans reveal that control of temporal patterning is analogous to the dedicated genetic pathways that control the patterning of the spatial axes in Drosophila and other metazoans. These pathways generate graded or binary levels of regulatory factors that pattern particular axes of the developing animal. C. elegans heterochronic genes constitute a regulatory cascade that both generates a temporal decrease in the level of the LIN-14 and LIN-28 proteins and responds to the changes in these gene activities to coordinate the temporal sequence of many cell fates as the animal develops. The temporal regulation of lin-14 and lin-28 gene activities is posttranscriptional and mediated by the antisense RNA product of the lin-4 gene. Hormonal control of developmental timing is a common theme throughou...Continue Reading

References

Oct 28, 1976·The New England Journal of Medicine·F BerthezèneR Mornex
Mar 1, 1977·Developmental Biology·J E Sulston, H R Horvitz
Apr 1, 1992·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·S J Gould
Jan 24, 1992·Cell·D St Johnston, C Nüsslein-Volhard
Dec 12, 1991·The New England Journal of Medicine·L S WeinsteinA M Spiegel
Jun 10, 1988·Science·C Kenyon
Oct 26, 1984·Science·V Ambros, H R Horvitz
Nov 1, 1983·Developmental Biology·J E SulstonJ N Thomson
Jul 1, 1995·Trends in Genetics : TIG·E J Lawson, R S Poethig
Jun 1, 1995·Plant Physiology·M M Evans, R S Poethig
Oct 25, 1994·Proceedings of the National Academy of Sciences of the United States of America·S K MannR A Firtel
Apr 1, 1994·Trends in Genetics : TIG·V Ambros, E G Moss
Mar 1, 1997·Trends in Genetics : TIG·K Iwasaki, J H Thomas

❮ Previous
Next ❯

Citations

Feb 13, 1999·Archives of Insect Biochemistry and Physiology·R FarkasD Jones
Jan 29, 2000·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·B Durand, M Raff
Jan 10, 2002·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Eric J Lambie
Apr 3, 2009·Chromosoma·Rachael A Nimmo, Frank J Slack
Jun 5, 2003·Developmental Biology·Wouter HouthoofdGaëtan Borgonie
Jul 20, 2002·Seminars in Cell & Developmental Biology·Heidi Scrable
Apr 26, 2008·Cell Death and Differentiation·E S BlumS Shaham
Jan 20, 2009·Nature Structural & Molecular Biology·Weiyang ShiBenjamin Haley
Apr 18, 2002·Genes & Development·Shai Shaham, Cornelia I Bargmann
Jul 27, 2002·Annual Review of Cell and Developmental Biology·Amy E Pasquinelli, Gary Ruvkun
Sep 24, 2004·BMC Developmental Biology·Tao LiuGarth I Patterson
May 1, 2007·BMC Developmental Biology·Jimmy Ouellet, Richard Roy
Jan 8, 2004·Genome Biology·Anton J EnrightDebora S Marks
Jan 30, 2003·RNA·Mariana Lagos-QuintanaThomas Tuschl
Aug 12, 2010·PLoS Genetics·Katherine Olsson-Carter, Frank J Slack
Mar 25, 2006·Future Oncology·Frank J Slack, Joanne B Weidhaas
Jan 5, 2000·Proceedings of the National Academy of Sciences of the United States of America·J KimG S Min
Jun 24, 2004·Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution·Christoph Peter Eduard Zollikofer, Marcia Silvia Ponce de León
May 28, 2005·The Plant Journal : for Cell and Molecular Biology·Mathieu IngouffFrédéric Berger
Oct 12, 2005·Developmental Dynamics : an Official Publication of the American Association of Anatomists·A Esquela-KerscherF J Slack
Apr 27, 2010·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Pradeep M JoshiJoel H Rothman
Dec 15, 2005·Zoology : Analysis of Complex Systems, ZACS·Jonas Blom, Clas Lilja
Nov 14, 2002·Annual Review of Genetics·Marcel TijstermanRonald H A Plasterk
Jun 30, 2000·Current Biology : CB·E G Moss
Jun 7, 2007·Current Biology : CB·Eric G Moss
Oct 28, 2008·Molecular Cell·Inha HeoV Narry Kim
Mar 2, 1999·Developmental Biology·C Q NguyenD H Fitch
Mar 29, 2002·Journal of Morphology·Kathleen K Smith
Dec 31, 2003·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Matthew G Voas, Ilaria Rebay
May 24, 2000·Developmental Dynamics : an Official Publication of the American Association of Anatomists·G Shemer, B Podbilewicz
Jun 2, 2005·In Vitro Cellular & Developmental Biology. Animal·Edward M BergerVeronica Dubrovskaya

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