Temporal Patterns of Motion in Flexion-extension and Pronation-supination in a Rat Model of Posttraumatic Elbow Contracture

Clinical Orthopaedics and Related Research
Chelsey L DunhamSpencer P Lake

Abstract

The elbow is highly susceptible to contracture, which affects up to 50% of patients who experience elbow trauma. Previously, we developed a rat model to study elbow contracture that exhibited features similar to the human condition, including persistently decreased ROM and increased capsule thickness/adhesions. However, elbow ROM was not quantitatively evaluated over time throughout contracture development and subsequent mobilization of the joint. The purposes of this study were (1) to quantify the time-dependent mechanics of contracture, including comparison of contracture after immobilization and free mobilization; and (2) to determine what changes occur in capsule and joint surface morphology that may support the altered joint mechanics. A total of 96 male Long-Evans rats were randomized into control and injury (unilateral soft tissue injury/immobilization) groups. Flexion-extension and pronation-supination joint mechanics (n = 8/group) were evaluated after 3, 7, 21, or 42 days of immobilization (IM) or after 42 days of IM with either 21 or 42 days of free mobilization (63 or 84 FM, respectively). After measuring joint mechanics, a subset of these limbs (n = 3/group) was prepared for histologic analysis and blinded sections ...Continue Reading

References

Dec 22, 1999·Archives of Physical Medicine and Rehabilitation·G TrudelM Brown
Feb 28, 2004·Journal of Biomechanical Engineering·Kevin A HildebrandNigel Shrive
Mar 17, 2004·Clinical Orthopaedics and Related Research·Kevin A HildebrandDavid A Hart
Jan 11, 2005·Archives of Physical Medicine and Rehabilitation·Guy TrudelHans K Uhthoff
Feb 24, 2005·Journal of Shoulder and Elbow Surgery·Marc R Safran, David Baillargeon
Apr 8, 2006·Clinical Orthopaedics and Related Research·Alejandro N BugnoneScott Humble
Jan 2, 2007·Clinical Orthopaedics and Related Research·Kevin A HildebrandDavid A Hart
Mar 21, 2007·Journal of Shoulder and Elbow Surgery·Mark S CohenCarol Muehleman
Dec 12, 2007·The Journal of Hand Surgery·Anneluuk L C Lindenhovius, Jesse B Jupiter
Feb 27, 2008·Clinical Orthopaedics and Related Research·Guy TrudelOdette Laneuville
May 17, 2008·Upsala Journal of Medical Sciences·Eiichi ChimotoEiji Itoi
Aug 8, 2008·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Yoshihiro HagiwaraEiji Itoi
May 4, 2011·The Journal of the American Academy of Orthopaedic Surgeons·Jay D Keener, Leesa M Galatz
Jul 22, 2011·The Journal of Bone and Joint Surgery. American Volume·Raymond E AnakweCharles M Court-Brown
Nov 8, 2011·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Matthew P AbdelJoaquin Sanchez-Sotelo
Aug 3, 2012·The Journal of Bone and Joint Surgery. American Volume·Charalambos P Charalambous, Bernard F Morrey
May 1, 1993·Journal of Shoulder and Elbow Surgery·G J KingK N An
Mar 19, 2013·Connective Tissue Research·Yutaka YabeEiji Itoi
May 15, 2013·Journal of Shoulder and Elbow Surgery·Erik J KramerBrian T Feeley
Sep 6, 2013·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Michael J MonumentKevin A Hildebrand
Mar 7, 2014·The Journal of Bone and Joint Surgery. American Volume·Job N DoornbergPeter Kloen
Mar 25, 2014·Musculoskeletal Surgery·I FusaroR Rotini
Jul 17, 2015·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Spencer P LakeLeesa M Galatz
Mar 18, 2016·Current Reviews in Musculoskeletal Medicine·Jos J MellemaJesse B Jupiter
Apr 1, 2014·Shoulder & Elbow·Samuel Kk LingWai Kit Ngai
Sep 8, 2016·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Akinori KaneguchiKaoru Yamaoka
Dec 6, 2016·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Ryo SasabeMinoru Okita
Jan 14, 2017·Journal of Shoulder and Elbow Surgery·Chelsey L DunhamSpencer P Lake
Apr 19, 2017·Journal of Biomechanical Engineering·Chelsey L DunhamSpencer P Lake

❮ Previous
Next ❯

Citations

Sep 20, 2018·Muscle & Nerve·Chelsey L DunhamSpencer P Lake
Mar 8, 2019·The Journal of Bone and Joint Surgery. American Volume·Chelsey L DunhamSpencer P Lake
Nov 23, 2020·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Alex J ReiterSpencer P Lake
Dec 2, 2020·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Chelsey L DunhamSpencer P Lake
Jan 8, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Chelsey DunhamGretchen Meyer
Apr 3, 2021·Trends in Pharmacological Sciences·William A BlessingMark W Grinstaff

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society
Spencer P LakeLeesa M Galatz
Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society
Ryo SasabeMinoru Okita
© 2022 Meta ULC. All rights reserved