Temporal profile of inflammatory response to fracture and hemorrhagic shock: Proposal of a novel long-term survival murine multiple trauma model

Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society
Christian KleberKlaus D Schaser

Abstract

Hemorrhagic shock (hS) interacts with the posttraumatic immune response and fracture healing in multiple trauma. Due to the lack of a long-term survival multiple trauma animal models, no standardized analysis of fracture healing referring the impact of multiple trauma on fracture healing was performed. We propose a new long-term survival (21 days) murine multiple trauma model combining hS (microsurgical cannulation of carotid artery, withdrawl of blood and continuously blood pressure measurement), femoral (osteotomy/external fixation) and tibial fracture (3-point bending technique/antegrade nail). The posttraumatic immune response was measured via IL-6, sIL-6R ELISA. The hS was investigated via macrohemodynamics, blood gas analysis, wet-dry lung ration and histologic analysis of the shock organs. We proposed a new murine long-term survival (21 days) multiple trauma model mimicking clinical relevant injury patterns and previously published human posttraumatic immune response. Based on blood gas analysis and histologic analysis of shock organs we characterized and standardized our murine multiple trauma model. Furthermore, we revealed hemorrhagic shock as a causative factor that triggers sIL-6R formation underscoring the fundamen...Continue Reading

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Citations

Aug 18, 2016·In Vitro Cellular & Developmental Biology. Animal·Guijuan FengDongmei Zhang
Jun 26, 2017·Current Osteoporosis Reports·Takehito Ono, Hiroshi Takayanagi
Mar 3, 2018·Naunyn-Schmiedeberg's Archives of Pharmacology·Kathrin KaiserAnita Ignatius
Oct 5, 2017·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Zhi QiaoUNKNOWN TREAT group
Aug 11, 2017·Clinical Orthopaedics and Related Research·Katrin BundkirchenClaudia Neunaber
Mar 14, 2019·European Journal of Trauma and Emergency Surgery : Official Publication of the European Trauma Society·Philipp StörmannBorna Relja

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