PMID: 8964892Apr 1, 1996Paper

Temporal regulation by adrenergic receptor stimulation of macrophage (M phi)-derived tumor necrosis factor (TNF) production post-LPS challenge

Journal of Neuroimmunology
T A IgnatowskiR N Spengler

Abstract

Macrophage (M phi) responsiveness can be regulated by various mediators, including those which emanate from, and mimic, the sympathetic nervous system. Whereas beta-adrenergic agonists suppress, alpha 2-adrenergic agonists augment lipopolysaccharide (LPS)-stimulated tumor necrosis factor (TNF) production and gene expressed. The susceptibility of M phi s to regulation of LPS-induced TNF production and mRNA accumulation was examined following beta-adrenergic and alpha 2-adrenergic receptor activation at specific time points post-LPS challenge. Complete Freund's adjuvant-elicited murine M phi s were incubated with LPS (30 ng/ml) in the presence or absence of adrenergic agonists or antagonists. We assessed the susceptibility of immunologically-activated M phi s to adrenergic receptor regulation: a) during the 1 h delay in the production of TNF after LPS-stimulation, and b) during the rapid increase in TNF production which follows. Disparate responsiveness of M phi s to adrenergic drugs was observed during this time course of TNF production and TNF mRNA accumulation. In particular, while the concomitant addition of an alpha 2-adrenergic antagonist and LPS resulted in 45% suppression of TNF production, this selective blockade of alph...Continue Reading

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Citations

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Jan 15, 2014·Autonomic Neuroscience : Basic & Clinical·Andrea L CerviAlan E Lomax
Jul 26, 2013·Immunological Investigations·Joshua HauserNader D Nader
Jun 30, 2000·Clinical Immunology : the Official Journal of the Clinical Immunology Society·T A IgnatowskiR N Spengler
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Feb 5, 2011·American Journal of Physiology. Gastrointestinal and Liver Physiology·Mark K Lukewich, Alan E Lomax
Sep 15, 2001·American Journal of Physiology. Gastrointestinal and Liver Physiology·S YangP Wang
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