Temporal regulation of chromatin during myoblast differentiation

Seminars in Cell & Developmental Biology
Akihito HaradaAnthony N Imbalzano

Abstract

The commitment to and execution of differentiation programmes involves a significant change in gene expression in the precursor cell to facilitate development of the mature cell type. In addition to being regulated by lineage-determining and auxiliary transcription factors that drive these changes, the structural status of the chromatin has a considerable impact on the transcriptional competence of differentiation-specific genes, which is clearly demonstrated by the large number of cofactors and the extraordinary complex mechanisms by which these genes become activated. The terminal differentiation of myoblasts to myotubes and mature skeletal muscle is an excellent system to illustrate these points. The MyoD family of closely related, lineage-determining transcription factors directs, largely through targeting to chromatin, a cascade of cooperating transcription factors and enzymes that incorporate or remove variant histones, post-translationally modify histones, and alter nucleosome structure and positioning via energy released by ATP hydrolysis. The coordinated action of these transcription factors and enzymes prevents expression of differentiation-specific genes in myoblasts and facilitates the transition of these genes from...Continue Reading

Citations

May 11, 2018·The Journal of Comparative Neurology·Melissa A LeeCarol A Mason
Oct 2, 2020·Cellular and Molecular Life Sciences : CMLS·Bernadette NeveIsabelle Van Seuningen
Oct 28, 2019·International Journal of Molecular Sciences·Aneta Tarczewska, Beata Greb-Markiewicz
Jul 21, 2020·Epigenetics : Official Journal of the DNA Methylation Society·Nandini Karthik, Reshma Taneja
Oct 18, 2020·Proteomics·Ben N StansfieldJatin G Burniston

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