PMID: 11920727Mar 29, 2002Paper

Temporal regulation of neuropilin-1 expression and sensitivity to semaphorin 3A in NGF- and NT3-responsive chick sensory neurons

Journal of Neurobiology
Ausra PondP C Letourneau

Abstract

The extracellular molecule semaphorin 3A (Sema3A) is proposed to be a negative guidance cue that participates in patterning DRG sensory axons in the developing chick spinal cord. During development Sema3A is first expressed throughout the spinal cord gray matter, but Sema3A expression later disappears from the dorsal horn, where small-caliber cutaneous afferents terminate. Sema3A expression remains in the ventral horn, where large-muscle proprioceptive afferents terminate. It has been proposed that temporal changes in the sensitivity of different classes of sensory afferents to Sema3A contribute to the different pathfinding of these sensory afferents. This study compared the expression of the semaphorin 3A receptor subunit, neuropilin-1, and the collapse response of growth cones to semaphorin 3A for NGF (cutaneous)- and NT3 (proprioceptive)-dependent sensory axons extended from E6-E10 chick embryos. Growth cones extended from E6 DRGs in NT3-containing medium expressed neuropilin-1 and collapsed in response to Sema3A. From E7 until E10 NT3-responsive growth cones expressed progressively lower levels of neuropilin-1, and were less sensitive to Sema3A. On the other hand, growth cones extended from DRGs in NGF-containing medium exp...Continue Reading

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Citations

Mar 23, 2004·Molecular and Cellular Neurosciences·Tam Thanh QuachPappachan E Kolattukudy
Jul 5, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Alison L DellJonathan A Raper
Jul 28, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Puneet DangAndrew J W Furley
Sep 24, 2015·Acta Biomaterialia·Aleesha M McCormickNic D Leipzig
Jul 11, 2008·The Journal of Investigative Dermatology·Junko YamaguchiYoshio Goshima
Feb 3, 2004·The Journal of Comparative Neurology·Thomas E DillonM William Rochlin
Jul 11, 2008·Journal of Neuroscience Research·Peter BannermanDavid Pleasure
Sep 23, 2011·Developmental Neurobiology·Diane M Snow
Aug 2, 2011·Developmental Neurobiology·Eduardo Macagno
Mar 3, 2005·Neuroscience Research·Tomoyuki Masuda, Takashi Shiga
Jul 13, 2004·Brain Research. Developmental Brain Research·P Hande OzdinlerReha S Erzurumlu
May 18, 2010·Developmental Biology·James K Kubilus, Thomas F Linsenmayer
May 16, 2018·Development·Esther T Stoeckli
Aug 12, 2004·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Lee SilverGianluca Gallo
Jan 24, 2007·Nature Reviews. Neuroscience·Frédéric Marmigère, Patrik Ernfors
Jan 25, 2006·The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology·Reha S ErzurumluMark F Jacquin
Mar 18, 2006·Neuroreport·Makoto TamuraMaki K Yamada
Jan 24, 2021·Scientific Reports·Xandor M SpijkersR Jeroen Pasterkamp
Feb 7, 2003·Development·Christopher N G AndersonDavid Tannahill

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