Temporal relationship between the sexually dimorphic spontaneous GH secretory profiles and hepatic STAT5 activity

Endocrinology
G S TannenbaumDavid J Waxman

Abstract

STAT5 transduces transcriptional responses to GH in liver and other tissues and is proposed to mediate the sexually dimorphic effects of plasma GH secretory profiles on rodent liver gene expression. Previous studies have suggested that STAT5 undergoes repeated activation in direct response to successive GH pulses in adult male rats, with STAT5 activation being desensitized in females by their more persistent pattern of GH exposure. These findings, however, were based on in vitro studies or single blood samples analyzed for GH in vivo. In view of the highly pulsatile nature of rat GH secretion, we presently examined these hypotheses by concurrent monitoring of spontaneous GH secretory profiles and hepatic STAT5 activity in conscious, free-moving adult male and female rats. Rats were killed at times associated with spontaneous peaks or troughs of the GH rhythm; livers were removed and analyzed for STAT5 DNA-binding activity. In males, liver STAT5 activity was highest during the initial phase (15-60 min) of a GH secretory episode (mean +/- SE relative STAT5 activity = 86.5 +/- 11.4; plasma GH = 146.7 +/- 22.4 ng/ml) and was significantly lower (P < 0.01) during the downswing of a pulse, 45-75 min after the GH peak (STAT5 = 26.1 +/...Continue Reading

References

Aug 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·D J WaxmanB H Shapiro
Jan 1, 1985·Endocrine Reviews·J O JanssonO Isaksson
Jan 1, 1995·The International Journal of Biochemistry & Cell Biology·B H ShapiroN A Pampori
Jul 8, 1997·Proceedings of the National Academy of Sciences of the United States of America·G B UdyH W Davey
Sep 12, 1997·Science·J E Darnell
Jan 19, 1999·Molecular Endocrinology·C A GebertD J Waxman
Jan 26, 1999·Cytokine & Growth Factor Reviews·A Yoshimura
Dec 10, 1999·The Journal of Biological Chemistry·P A Ram, D J Waxman
Apr 1, 2000·Cytokine & Growth Factor Reviews·P M GrimleyH Rui
Jun 13, 2000·Oncogene·J HerringtonC Carter-Su

❮ Previous
Next ❯

Citations

Nov 8, 2005·Proceedings of the National Academy of Sciences of the United States of America·Xavier BonnefontPatrice Mollard
Mar 24, 2004·Genes & Development·François TroncheGünther Schütz
Jun 2, 2009·Molecular Pharmacology·David J Waxman, Minita G Holloway
Dec 17, 2004·Molecular and Cellular Biology·Jennifer E RowlandMichael J Waters
Jul 12, 2008·The Journal of Clinical Investigation·Joshua H WongEthan J Weiss
Jul 11, 2009·Endocrine Reviews·Claes OhlssonJohan Svensson
May 17, 2008·Molecular Endocrinology·Valerie Wauthier, David J Waxman
May 11, 2006·Drug Metabolism Reviews·Agneta Mode, Jan-Ake Gustafsson
Jan 26, 2008·Hormone Research·A M Lichanska, M J Waters
May 8, 2008·Medicine and Science in Sports and Exercise·Leslie A ConsittRon F Morrison
Mar 18, 2006·Molecular Endocrinology·David J Waxman, Caitlin O'Connor
May 25, 2004·Molecular Endocrinology·Christopher A WiwiDavid J Waxman
Dec 3, 2008·The Journal of Physiology·Jenny M OldhamChristopher D McMahon
Aug 25, 2018·International Journal of Endocrinology·Yang-Ming Yang, Pravin B Sehgal
Sep 13, 2005·The Journal of Biological Chemistry·Tanya Landsman, David J Waxman
Nov 13, 2004·The Journal of Biological Chemistry·Christopher A Wiwi, David J Waxman
Oct 1, 2004·Molecular & Cellular Proteomics : MCP·Ekaterina V LazDavid J Waxman
Apr 18, 2006·Environmental Research·Michael Gochfeld

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.