PMID: 6108273Sep 1, 1980Paper

Temporal relationship of tissue somatostatin-like immunoreactivity to metabolic changes in genetically obese and diabetic mice

Diabetes
M BerelowitzL A Frohman

Abstract

Somatostatin-like immunoreactivity (SRIF-LI) content in 2 N acetic acid extracts of hypothalamus, gastric antrum, and pancreas was measured in genetically obese (C57BL/6J ob/ob and db/db) and diabetic (C57BL/KsJ db/db and ob/ob) mice and normal littermate controls from 5 to 24 wk to determine the relationship of previously reported changes to the development of metabolic abnormalities. Hypothalamic SRIF-L concentration was similar in control, diabetic, and obese mice at all ages and increased progressively with age in all groups. Gastric antrum SRIF-LI was similar in all groups of mice at all ages. Obese mice gained weight progressively and showed moderate hyperglycemia and marked hyperinsulinemia from 5 wk of age. Pancreatic SRIF-LI content in obese (C57BL/6J) animals was similar to that in lean littermate controls, but pancreatic SRIF-LI concentration (expressed by weight or protein content) was decreased until 8 (6J ob/ob) and 10 (6J db/db) wk. Diabetic (C57BL/KsJ) mice showed a similar metabolic pattern until 10 wk with no change in pancreatic SRIF-LI content or concentration. Thereafter a progressive fall in serum insulin and a marked rise in serum glucose was associated with increasing pancreatic SRIF-LI content and conce...Continue Reading

Citations

Jan 1, 1986·Scandinavian Journal of Gastroenterology. Supplement·V Schusdziarra, R Schmid
May 1, 1982·Metabolism: Clinical and Experimental·H K WilsonH H Conaway
Dec 1, 1989·Early Human Development·A M WidströmK Uvnäs-Moberg
Aug 1, 1989·Diabetic Medicine : a Journal of the British Diabetic Association·G Williams, S R Bloom
Sep 1, 1989·Diabetic Medicine : a Journal of the British Diabetic Association·G WilliamsS R Bloom

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