Temporal relationship of viral load, ribavirin, interleukin (IL)-6, IL-8, and clinical progression in patients with severe acute respiratory syndrome

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Wei-Kung WangSevere Acute Respiratory Syndrome Research Group of the National Taiwan University College of Medicine/NTU Hospital


Although viral replication and overwhelming immune responses are believed to contribute to the progression of severe acute respiratory syndrome (SARS), little is known about the temporal relationship between viral load, ribavirin, proinflammatory cytokines, and clinical progression. We report that ribavirin was not effective in reducing the SARS coronavirus load in 3 of 8 probable cases studied and that elevated levels of interleukin (IL)-6 and IL-8 subsequent to the peak viral load were found in 8 and 6 cases, respectively. The nadir lymphocyte count during lymphopenia, the peak level of lactate dehydrogenase, and the peak density of pulmonary infiltrates lag further behind the peak viral load by a median of 4, 5, and 3.5 days, respectively. These findings provide important information for therapeutic strategies to treat SARS.


Apr 16, 2003·The New England Journal of Medicine·Nelson LeeJoseph J Y Sung
Apr 12, 2003·The New England Journal of Medicine·Christian DrostenHans Wilhelm Doerr
Apr 12, 2003·The New England Journal of Medicine·Thomas G KsiazekUNKNOWN SARS Working Group
May 8, 2003·JAMA : the Journal of the American Medical Association·Christopher M BoothAllan S Detsky
Jun 5, 2003·Lancet·John M NichollsJ S Malik Peiris
Jun 21, 2003·BMJ : British Medical Journal·Raymond S M WongJoseph J Y Sung
Oct 2, 2003·Emerging Infectious Diseases·Po-Ren HsuehUNKNOWN SARS Research Group of National Taiwan University College of Medicine and National Taiwan University Hospital
Dec 19, 2003·The New England Journal of Medicine·Joseph S M PeirisKlaus Stöhr
Jun 18, 2004·Emerging Infectious Diseases·Jann-Tay WangPan-Chyr Yang
Jun 25, 2004·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·Y O Y SooJ J Y Sung
Aug 25, 2004·Emerging Infectious Diseases·Wei-Kung WangUNKNOWN SARS Research Group of the National Taiwan University/National Taiwan University Hospital

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