Temporal relationships between eating behavior and liver adenine nucleotides in rats treated with 2,5-AM

The American Journal of Physiology
J E KochM I Friedman

Abstract

Administration of the fructose analog 2,5-anhydro-D-mannitol (2,5-AM) elicits eating behavior in rats by its action in the liver. To evaluate whether the decrease in liver ATP levels produced by injection of 2,5-AM plays a role in the eating response, we examined the relationship between changes in eating behavior and liver adenine nucleotide levels over time in rats given 2,5-AM. Liver ATP concentrations decreased within 15 min after injection of 2,5-AM (300 mg/kg ip), remained low for up to 90 min postinjection, and returned to control (saline injection) levels by 4 h after treatment. Rats fed ad libitum initiated eating between 15 and 45 min after 2,5-AM treatment, after liver ATP levels had declined. Rats given food 1 h after 2,5-AM treatment increased food intake, but if access to food was delayed for 4 h after 2,5-AM injection the eating response was attenuated or absent. Whereas liver AMP and ADP levels were also altered by injection of 2,5-AM, changes in food intake did not consistently track changes in these nucleotides. The results support the hypothesis that the eating response to 2,5-AM is triggered by a decrease in liver ATP level.

References

Dec 1, 1991·Journal of Molecular and Cellular Cardiology·G S Sandhu, G K Asimakis
Jun 1, 1990·Appetite·D R Reed, M I Friedman
Jun 30, 1985·Biochimica Et Biophysica Acta·H C StevensW L Dills
Jan 1, 1995·Annual Review of Biochemistry·C B Newgard, J D McGarry

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Citations

Jun 10, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·H JiM I Friedman
Sep 1, 2016·American Journal of Physiology. Endocrinology and Metabolism·Brennan K SmithGregory R Steinberg
Feb 8, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Mark I FriedmanMary D Osbakken
Feb 8, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Hong JiMark I Friedman

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