Temporal release pattern of copeptin and troponin T in patients with suspected acute coronary syndrome and spontaneous acute myocardial infarction

Clinical Chemistry
Anna SlagmanMartin Möckel

Abstract

The release pattern of copeptin during the initial 36 h of spontaneous acute myocardial infarction (AMI) has received relatively little investigation but may provide important information on optimal timing of diagnostic measurements. We investigated the release pattern of copeptin and cardiac troponin T in patients with suspected acute coronary syndrome (ACS). Blood samples were collected in the ambulance, at admission, and after 2, 4, 6, and 12-36 h. Copeptin and high-sensitivity cardiac troponin T (hs-cTnT) were measured in heparin plasma samples. Of 93 patients studied, 37 (39.8%) had ST-elevation myocardial infarction (STEMI), 20 (21.5%) non-STEMI, 20 (21.5%) unstable angina pectoris (UAP), and 16 (17.2%) non-ACS diagnoses. Peak copeptin concentrations were detected during ambulance transport for NSTEMI patients [median 94.0 pmol/L, interquartile range (IQR) 53.3-302.1 pmol/L] and at admission for patients with STEMI (70.0 pmol/L, 22.0-144.8 pmol/L). In patients with AMI, copeptin decreased significantly over time (P < 0.0001). This was true for patients with STEMI (P = 0.005) and non-STEMI (P = 0.021). The diagnostic performance during ambulance transport was similar for hs-cTnT (area under the ROC curve 0.75, 95% CI 0.62-...Continue Reading

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Citations

Aug 31, 2016·International Journal of Cardiology·Kris G VargasKurt Huber
Oct 25, 2016·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Marius SchwergVerena Stangl
Dec 3, 2016·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Carsten StengaardKristian Thygesen
Mar 26, 2016·European Heart Journal. Acute Cardiovascular Care·Fabio StalloneChristian Mueller
Jan 6, 2017·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Assi MilwidskyYacov Shacham
Jun 9, 2017·European Heart Journal. Acute Cardiovascular Care·Christian MuellerUNKNOWN ESC Study Group on Biomarkers in Cardiology of the Acute Cardiovascular Care Association
Oct 28, 2015·Clinical Chemistry·Benjamin M Scirica, David A Morrow
Dec 1, 2016·Diagnosis·Carsten StengaardChristian Juhl Terkelsen
Jan 7, 2020·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Mathias Alexander HøjagergaardMartin Frydland
Dec 1, 2020·Current Problems in Cardiology·J A Reyes-Retana, L C Duque-Ossa
Oct 14, 2020·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Evangelos GiannitsisKurt Huber

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