Temporal requirement for hedgehog signaling in ventral telencephalic patterning

Development
Marc FuccilloGord Fishell

Abstract

Hedgehog signaling is required for multiple aspects of brain development, including growth, the establishment of both dorsal and ventral midline patterning and the generation of specific cell types such as oligodendrocytes and interneurons. To identify more precisely when during development hedgehog signaling mediates these events, we directed the removal of hedgehog signaling within the brain by embryonic day 9 of development, using a FoxG1(Cre) driver line to mediate the removal of a conditional smoothened null allele. We observed a loss of ventral telencephalic patterning that appears to result from an initial lack of specification of these structures rather than by changes in proliferation or cell death. A further consequence of the removal of smoothened in these mice is the near absence of both oligodendrocytes and interneurons. Surprisingly, the dorsal midline appears to be patterned normally in these mutants. Together with previous analyses, the present results demonstrate that hedgehog signaling in the period between E9.0 and E12 is essential for the patterning of ventral regions and the generation of cell types that are thought to largely arise from them.

References

Sep 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·S LuF H Ruddle
Jan 1, 1993·Methods in Enzymology·D G Wilkinson, M A Nieto
Jul 27, 1999·Developmental Dynamics : an Official Publication of the American Association of Anatomists·V HatiniE Lai
Oct 21, 1999·Molecular Genetics and Metabolism·D E Wallis, M Muenke
May 29, 2000·Current Opinion in Genetics & Development·M Muenke, P A Beachy
Dec 4, 2001·Genes & Development·P W Ingham, A P McMahon
Jun 7, 2002·Nature·Kresimir LetinicPasko Rakic

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Citations

Oct 7, 2008·Nature Genetics·Yongsu JeongDouglas J Epstein
Jan 3, 2006·Nature Neuroscience·Nicoletta KessarisWilliam D Richardson
Jan 24, 2006·Nature Reviews. Neuroscience·Giuseppe LupoKatharine E Lewis
Jan 15, 2009·Nature Reviews. Neuroscience·Jean M Hébert, Gord Fishell
Apr 25, 2012·Development, Growth & Differentiation·Daisuke H Tanaka, Kazunori Nakajima
May 9, 2012·Anatomy Research International·A E EvansA E Rosser
Sep 19, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Eric S TuckerAnthony-Samuel Lamantia
Apr 1, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Miki FurushoRashmi Bansal
Jun 14, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Nicole ArbourRuth S Slack
Apr 3, 2010·ASN Neuro·Luis R Hernández-MirandaFrancesca Chiara
Sep 10, 2005·Molecular and Cellular Neurosciences·Ondrej MachonZbynek Kozmik
Aug 13, 2014·Proceedings of the National Academy of Sciences of the United States of America·Cheuk Ka TongArturo Alvarez-Buylla
Aug 12, 2014·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jianhua Chu, Stewart A Anderson
Mar 2, 2006·Developmental Neuroscience·Heather A MasonGord Fishell
Nov 28, 2013·Proceedings of the National Academy of Sciences of the United States of America·Taisuke KadoshimaYoshiki Sasai
Feb 21, 2016·Developmental Biology·Daichi KawaguchiDennis D M O'Leary
May 15, 2010·Current Opinion in Genetics & Development·Vitor H Sousa, Gord Fishell
Jul 26, 2005·Journal of Neurobiology·M Natalia VergaraKatia Del Rio-Tsonis
Oct 23, 2008·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Thomas TheilThomas Schimmang
Oct 20, 2007·Developmental Neurobiology·Monica HayhurstSusan K McConnell
Oct 25, 2006·Birth Defects Research. Part C, Embryo Today : Reviews·Hiroshi Takahashi, Fu-Chin Liu
Apr 9, 2008·Clinical Genetics·M Fernandes, J M Hébert
Nov 23, 2011·The European Journal of Neuroscience·Paul G Anastasiades, Simon J B Butt
Nov 28, 2009·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Ricardo Noboro IsayamaEdna Nanami Yamasaki
Sep 15, 2015·Methods : a Companion to Methods in Enzymology·Sandra AhnSangmi Chung
Jan 27, 2015·Wiley Interdisciplinary Reviews. Developmental Biology·Roberta AzzarelliAnna Philpott
May 16, 2013·Stem Cell Research·Timothy J PetrosStewart A Anderson
May 26, 2011·Neuron·David V HansenArnold R Kriegstein

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