Temporal responses to intrinsically coupled calcium and zinc dyshomeostasis in cardiac myocytes and mitochondria during aldosteronism.

American Journal of Physiology. Heart and Circulatory Physiology
German KamalovKarl T Weber

Abstract

Intracellular Ca(2+) overloading, coupled to induction of oxidative stress, is present at 4-wk aldosterone/salt treatment (ALDOST). This prooxidant reaction in cardiac myocytes and mitochondria accounts for necrotic cell death and subsequent myocardial scarring. It is intrinsically linked to increased intracellular zinc concentration ([Zn(2+)](i)) serving as an antioxidant. Herein, we addressed the temporal responses in coupled Ca(2+) and Zn(2+) dyshomeostasis, reflecting the prooxidant-antioxidant equilibrium, by examining preclinical (week 1) and pathological (week 4) stages of ALDOST to determine whether endogenous antioxidant defenses would be ultimately overwhelmed to account for this delay in cardiac remodeling. We compared responses in cardiomyocyte free [Ca(2+)](i) and [Zn(2+)](i) and mitochondrial total [Ca(2+)](m) and [Zn(2+)](m), together with biomarkers of oxidative stress and antioxidant defenses, during 1- and 4-wk ALDOST. At week 1 and compared with controls, we found: 1) elevations in [Ca(2+)](i) and [Ca(2+)](m) were coupled with [Zn(2+)](i) and [Zn(2+)](m); 2) increased mitochondrial H(2)O(2) production, cardiomyocyte xanthine oxidase activity, and cardiac and mitochondrial 8-isoprostane levels, counterbalanced...Continue Reading

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Citations

Feb 14, 2012·Pflügers Archiv : European journal of physiology·M Usman KhanKarl T Weber
Apr 21, 2010·Heart Failure Reviews·Malay S GandhiKarl T Weber
Sep 10, 2010·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Ayhan A ZiaKarl T Weber
Mar 15, 2011·European Heart Journal·Brian J BorkowskiKarl T Weber
Sep 18, 2010·Journal of Hypertension·Atta U ShahbazKarl T Weber
Jan 7, 2010·Journal of Cardiovascular Pharmacology·German KamalovKarl T Weber
Jul 1, 2010·Journal of Cardiovascular Pharmacology·German KamalovKarl T Weber
Oct 23, 2010·Journal of Cardiovascular Pharmacology·Atta U ShahbazKarl T Weber
Jun 26, 2012·American Journal of Physiology. Heart and Circulatory Physiology·Yaser CheemaKarl T Weber
Nov 16, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Atta U ShahbazKarl T Weber
Nov 2, 2012·Current Heart Failure Reports·Michael R SeawellKarl T Weber
Mar 1, 2012·Cardiovascular Drugs and Therapy·Michael R RutledgeKarl T Weber
Jul 13, 2011·The American Journal of the Medical Sciences·Antwon D RobinsonKarl T Weber
Jan 18, 2011·The American Journal of the Medical Sciences·Ayhan A ZiaKarl T Weber
Jul 25, 2012·Progress in Cardiovascular Diseases·Jawwad YusufKarl T Weber
Jun 17, 2016·Journal of Receptor and Signal Transduction Research·Carolina Morais AraujoMauro César Isoldi
Nov 13, 2014·Hormone Molecular Biology and Clinical Investigation·Beatriz Martín-FernándezVicente Lahera
Nov 16, 2017·International Journal of Molecular Sciences·Belma Turan, Erkan Tuncay
Sep 18, 2010·Journal of Hypertension·Fedor Simko, Olga Pechanova
Aug 8, 2013·Journal of Cardiovascular Pharmacology·M Usman KhanKarl T Weber
Oct 8, 2014·Journal of Cardiovascular Pharmacology·Nephertiti EfeovbokhanKarl T Weber
Jan 21, 2021·Free Radical Biology & Medicine·Yoshiro TanakaMichihiro Yoshimura

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