Temporal sequence of changes in electrophysiological properties of oculomotor motoneurons during postnatal development

Neuroscience
L CarrascalB Torres

Abstract

The temporal sequence of changes in electrophysiological properties during postnatal development in different neuronal populations has been the subject of previous studies. Those studies demonstrated major physiological modifications with age, and postnatal periods in which such changes are more pronounced. Until now, no similar systematic study has been performed in motoneurons of the oculomotor nucleus. This work has two main aims: first, to determine whether the physiological changes in oculomotor nucleus motoneurons follow a similar time course for different parameters; and second, to compare the temporal sequence with that in other neuronal populations. We recorded the electrophysiological properties of 134 identified oculomotor nucleus motoneurons from 1 to 40 days postnatal in brain slices of rats. The resting membrane potential did not significantly change with postnatal development, and it had a mean value of -61.8 mV. The input resistance and time constant diminished from 82.9-53.1 M omega and from 9.4-4.9 ms respectively with age. These decrements occurred drastically in a short time after birth (1-5 days postnatally). The motoneurons' rheobase gradually decayed from 0.29-0.11 nA along postnatal development. From bir...Continue Reading

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Citations

Jul 21, 2010·Cerebral Cortex·Jose Luis Nieto-GonzalezKimmo Jensen
Mar 11, 2009·The Journal of Comparative Neurology·Livia CarrascalPedro Nunez-Abades
Apr 27, 2007·The European Journal of Neuroscience·Jose Luis Nieto-GonzalezBlas Torres
Jun 18, 2011·The Journal of Comparative Neurology·Michael A FoxJeff W Lichtman
Oct 31, 2008·Journal of Neurophysiology·Jose Luis Nieto-GonzalezBlas Torres
Oct 16, 2009·Journal of Neurophysiology·Arnaud Pambo-PamboJean-Patrick Gueritaud
Sep 16, 2021·Annual Review of Vision Science·Anja K E Horn, Hans Straka

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