Temporal stability of network centrality in control and default mode networks: Specific associations with externalizing psychopathology in children and adolescents

Human Brain Mapping
João Ricardo SatoRodrigo Affonseca Bressan

Abstract

Abnormal connectivity patterns have frequently been reported as involved in pathological mental states. However, most studies focus on "static," stationary patterns of connectivity, which may miss crucial biological information. Recent methodological advances have allowed the investigation of dynamic functional connectivity patterns that describe non-stationary properties of brain networks. Here, we introduce a novel graphical measure of dynamic connectivity, called time-varying eigenvector centrality (tv-EVC). In a sample 655 children and adolescents (7-15 years old) from the Brazilian "High Risk Cohort Study for Psychiatric Disorders" who were imaged using resting-state fMRI, we used this measure to investigate age effects in the temporal in control and default-mode networks (CN/DMN). Using support vector regression, we propose a network maturation index based on the temporal stability of tv-EVC. Moreover, we investigated whether the network maturation is associated with the overall presence of behavioral and emotional problems with the Child Behavior Checklist. As hypothesized, we found that the tv-EVC at each node of CN/DMN become more stable with increasing age (P < 0.001 for all nodes). In addition, the maturity index for...Continue Reading

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Citations

Jun 12, 2016·Developmental Cognitive Neuroscience·João Ricardo SatoAndrea Parolin Jackowski
Jun 25, 2017·NeuroImage·Ankit N KhambhatiDanielle S Bassett
Nov 6, 2018·European Child & Adolescent Psychiatry·João Ricardo SatoAndrea Parolin Jackowski
Dec 6, 2017·Human Brain Mapping·Ashkan FaghiriVince D Calhoun
Jun 22, 2017·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·João Ricardo SatoRodrigo Affonseca Bressan
Oct 20, 2020·Journal of Personality Disorders·Mohammad H AfzaliPatricia Conrod
Nov 25, 2020·Biological Psychiatry : Cognitive Neuroscience and Neuroimaging·Nicole R KarcherDeanna M Barch
Mar 13, 2018·Biological Psychiatry : Cognitive Neuroscience and Neuroimaging·Katherine H KarlsgodtAnil K Malhotra

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