Temporal summation of pressure pain during muscle hyperalgesia evoked by nerve growth factor and eccentric contractions

European Journal of Pain : EJP
HongLing NieT Graven-Nielsen

Abstract

Nerve growth factor (NGF) has a key role in the generation and potentiation of pain. Its centrally sensitizing effects may facilitate pain responses to noxious stimulus. This study assessed (1) the influence of NGF on delayed onset muscle soreness (DOMS) in shoulder muscles; and (2) the temporal summation of pressure pain during hyperalgesia induced by NGF and DOMS. In a blinded design, 10 healthy subjects were injected with NGF in the trapezius muscle on one side and with isotonic saline on the contralateral side as control. The subjects undertook shoulder eccentric exercise to induce DOMS in the shoulder muscles 3h after the injections. The soreness intensity to muscle contraction, pressure pain thresholds (PPT), and pain intensity to sequential stimuli (i.e. temporal summation at 1 and 30s inter-stimulus interval (ISI)) were assessed before injections - 3, 24h, and 4, 7, and 21 days after injections. The soreness intensity to muscle contraction significantly increased at 3 and 24h in both shoulders (P<0.05) and went back to baseline levels at day 7. The same development was seen in PPT as reduced thresholds (P<0.05). The NGF injected side had higher pain ratings during temporal summation at 1s ISI compared with the contralat...Continue Reading

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Citations

Aug 1, 2012·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Helen SlaterStephan A Schug
Oct 22, 2011·Expert Review of Neurotherapeutics·Lars Arendt-Nielsen, Hans Christian Hoeck
Jul 17, 2015·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Michael Joseph Gerard BerginThomas Graven-Nielsen
Apr 18, 2013·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Tanja Schjoedt JoergensenThomas Graven-Nielsen
Dec 23, 2014·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Djordje Adnadjevic, Thomas Graven-Nielsen
Jan 3, 2012·The Journal of Pain : Official Journal of the American Pain Society·Carolina ValenciaSteven Z George
Jan 6, 2010·European Journal of Pain : EJP·Tetsurou TorisuLars Arendt-Nielsen
Jun 19, 2012·Pain·Saskia DeisingRoman Rukwied
Jan 3, 2012·The Spine Journal : Official Journal of the North American Spine Society·Mark D BishopSteven Z George
Jul 29, 2010·Nature Reviews. Rheumatology·Thomas Graven-Nielsen, Lars Arendt-Nielsen
Oct 29, 2010·Journal of Neurophysiology·Akhlaq W HakimBrian E Cairns
Jul 18, 2019·European Journal of Pain : EJP·Line Bay SørensenThomas Graven-Nielsen
May 17, 2019·Pain·Simon J SummersSiobhan M Schabrun
May 28, 2019·Frontiers in Physiology·Stéphanie HodyPierre Leprince
Jun 18, 2020·Journal of Pain Research·Philip A BarkerLeslie Tive
Jun 19, 2018·Scandinavian Journal of Pain·Tanja Schjødt JørgensenThomas Graven-Nielsen
Oct 29, 2020·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Line Bay SørensenThomas Graven-Nielsen
Mar 10, 2017·The Clinical Journal of Pain·Kristian K PetersenThomas Graven-Nielsen
Jun 29, 2021·The Journal of Pain : Official Journal of the American Pain Society·Enrico De MartinoThomas Graven-Nielsen

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