Jul 21, 2017

Temporal transitions of spontaneous brain activity

BioRxiv : the Preprint Server for Biology
Zhiwei Ma, Nanyin Zhang

Abstract

Spontaneous brain activity is typically investigated using resting-state fMRI (rsfMRI), which measures resting-state functional connectivity (RSFC) between brain regions. Previous rsfMRI studies mainly focused on spatial characteristics of RSFC. However, it remains elusive whether characteristic RSFC patterns temporally fluctuate in a random order, or transit in specific sequences. Here we investigated temporal transitions between characteristic RSFC patterns in awake rats. We found that transitions between RSFC patterns were highly reproducible across animals and significantly above chance, suggesting that RSFC pattern transitions were nonrandom. The global organization of RSFC pattern transitions was further examined by analyzing the RSFC pattern transition network using graph theory. Its community structure and pivotal RSFC patterns in temporal transitions were identified. Taken together, this study has revealed the temporal relationship between characteristic RSFC spatial patterns in the awake rat brain. It offers new insights into understanding the spatiotemporal dynamics of spontaneous brain activity.

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Mentioned in this Paper

Study
Patterns
Spatial Distribution
Brain
FMRI
Brain Activity
Structure
Rat Brain
Interphase Cell

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