Temporal trends in acute myocardial infarction presentation and association with use of cardioprotective drugs: a nationwide registry-based study

European Heart Journal. Cardiovascular Pharmacotherapy
Laerke SmedegaardPeter Riis Hansen

Abstract

The present study aimed to investigate temporal trends in myocardial infarction (MI) presentation with or without ST-segment elevation and the association with the use of cardioprotective drugs prior to admission. Using individual-level linkage of data from Danish nationwide registries, we identified all patients 30 years or older admitted with a first-time MI in the period 2003-2012, and their use of cardioprotective drugs 6 months prior to admission. We calculated incidence rates per 100 000 person-years (IRs) of ST-segment elevation MI (STEMI) and non-STEMI (NSTEMI). We identified 22 247 patients admitted with STEMI and 50 403 with NSTEMI. IRs for NSTEMI decreased by 35% from 194 in 2003 to 126 in 2012, whereas IRs for STEMI peaked in 2007 and subsequently declined from 71 to 65. Preadmission use of cardioprotective drugs increased in both groups from 2003 to 2012. Patients admitted with STEMI had odds ratio (OR) 0.64 [95% confidence interval (CI) 0.61-0.67] for preadmission use of aspirin compared with patients admitted with NSTEMI. Corresponding ORs were 0.82 (CI 0.78-0.87) for statins, 0.87 (CI 0.82-0.91) for beta-blockers, 0.89 (CI 0.85-0.92) for angiotensin-converting enzyme inhibitors/angiotensin receptor blockers, and...Continue Reading

References

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Citations

Aug 8, 2020·Clinical Cardiology·Saraschandra VallabhajosyulaBernard J Gersh
May 19, 2021·The American Journal of Cardiology·Saraschandra VallabhajosyulaBernard J Gersh
Jul 29, 2021·Journal of the American Heart Association·Sadaf KamilHelena Dominguez

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