Temporal trends in hyperuricaemia in the Irish health system from 2006-2014: A cohort study

PloS One
Arun Kumar A UA G Stack

Abstract

Elevated serum uric acid (sUA) concentrations are common in the general population and are associated with chronic metabolic conditions and adverse clinical outcomes. We evaluated secular trends in the burden of hyperuricaemia from 2006-2014 within the Irish health system. Data from the National Kidney Disease Surveillance Programme was used to determine the prevalence of elevated sUA in adults, age > 18 years, within the Irish health system. Hyperuricaemia was defined as sUA > 416.4 μmol/L in men and > 339.06 μmol/L in women, and prevalence was calculated as the proportion of patients per year with mean sUA levels above sex-specific thresholds. Temporal trends in prevalence were compared from 2006 to 2014 while general estimating equations (GEE) explored variation across calendar years expressed as odds ratios (OR) and 95% Confidence intervals (CI). From 2006 to 2014, prevalence of hyperuricaemia increased from 19.7% to 25.0% in men and from 20.5% to 24.1% in women, P<0.001. The corresponding sUA concentrations increased significantly from 314.6 (93.9) in 2006 to 325.6 (96.2) in 2014, P<0.001. Age-specific prevalence increased in all groups from 2006 to 2014, and the magnitude of increase was similar for each age category. Adj...Continue Reading

References

Sep 19, 2008·Journal of the American Society of Nephrology : JASN·Rudolf P ObermayrRenate Klauser-Braun
Dec 10, 2008·Statistics in Medicine·Lin-Yee Hin, You-Gan Wang
Feb 25, 2009·Archives of Internal Medicine·Chi-yuan HsuAlan S Go
May 6, 2009·Annals of Internal Medicine·Andrew S LeveyUNKNOWN CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration)
Jul 1, 2009·Arthritis and Rheumatism·Seo Young KimDaniel A Albert
Mar 2, 2010·Arthritis Care & Research·Seo Young KimDaniel A Albert
Sep 9, 2010·Arthritis Care & Research·Peter C GraysonHyon K Choi
Jun 28, 2012·Annals of the Rheumatic Diseases·Gianluca TrifiròGiampiero Mazzaglia
Oct 24, 2012·Advances in Chronic Kidney Disease·Mariana Murea
Apr 9, 2013·QJM : Monthly Journal of the Association of Physicians·A G StackH T Nguyen
Jul 3, 2015·Journal of Hypertension·Claudio BorghiGiuseppe Mancia
Sep 29, 2015·Current Medical Research and Opinion·A StackE Ritz
Jul 28, 2016·Annals of the Rheumatic Diseases·P RichetteT Bardin
Dec 3, 2017·International Journal of Medical Informatics·John FergusonAustin Stack

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Citations

Sep 4, 2018·Modern Rheumatology·Masayuki Hakoda, Fumiyoshi Kasagi
Dec 1, 2018·Clinical Rheumatology·Xing Zhen LiuDong Bao Zhao
Oct 27, 2020·European Journal of Nutrition·Yingjie GuoZibin Tian
Oct 20, 2020·The Journal of Clinical Endocrinology and Metabolism·Austin G StackFredrik Erlandsson
Jan 10, 2021·International Journal of Environmental Research and Public Health·Mateusz WinderJerzy Chudek
Nov 17, 2020·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Jing-Hong LiuChen-Wei Pan

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