Temporal Trends in Incidence, Sepsis-Related Mortality, and Hospital-Based Acute Care After Sepsis

Critical Care Medicine
Nathaniel MeyerMark E Mikkelsen

Abstract

A growing number of patients survive sepsis hospitalizations each year and are at high risk for readmission. However, little is known about temporal trends in hospital-based acute care (emergency department treat-and-release visits and hospital readmission) after sepsis. Our primary objective was to measure temporal trends in sepsis survivorship and hospital-based acute care use in sepsis survivors. In addition, because readmissions after pneumonia are subject to penalty under the national readmission reduction program, we examined whether readmission rates declined after sepsis hospitalizations related to pneumonia. Retrospective, observational cohort study conducted within an academic healthcare system from 2010 to 2015. We used three validated, claims-based approaches to identify 17,256 sepsis or severe sepsis hospitalizations to examine trends in hospital-based acute care after sepsis. None. From 2010 to 2015, sepsis as a proportion of medical and surgical admissions increased from 3.9% to 9.4%, whereas in-hospital mortality rate for sepsis hospitalizations declined from 24.1% to 14.8%. As a result, the proportion of medical and surgical discharges at-risk for hospital readmission after sepsis increased from 2.7% to 7.8%. O...Continue Reading

References

Jan 1, 1985·Statistics in Medicine·J Cuzick
Apr 12, 2003·Critical Care Medicine·Mitchell M LevyUNKNOWN SCCM/ESICM/ACCP/ATS/SIS
Oct 28, 2010·JAMA : the Journal of the American Medical Association·Theodore J IwashynaKenneth M Langa
Apr 5, 2012·JAMA : the Journal of the American Medical Association·Peter K LindenauerMichael B Rothberg
Jan 24, 2013·JAMA : the Journal of the American Medical Association·Kumar DharmarajanHarlan M Krumholz
Jan 24, 2013·JAMA : the Journal of the American Medical Association·Anita A VashiCary P Gross
Feb 28, 2013·Critical Care Medicine·David F GaieskiBrendan G Carr
Nov 10, 2013·Critical Care Medicine·Elizabeth K StevensonAllan J Walkey
Mar 19, 2014·JAMA : the Journal of the American Medical Association·Theodore J Iwashyna, Derek C Angus
Mar 19, 2014·JAMA : the Journal of the American Medical Association·Kirsi-Maija KaukonenRinaldo Bellomo
May 14, 2014·JAMA Internal Medicine·Aaron L LeppinVictor M Montori
May 30, 2014·American Journal of Respiratory and Critical Care Medicine·Hallie C PrescottTheodore J Iwashyna
Sep 27, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Chanu RheeUNKNOWN Centers for Disease Control and Prevention Epicenters Program
Oct 8, 2014·JAMA : the Journal of the American Medical Association·Colin R Cooke, Theodore J Iwashyna
Nov 5, 2014·Critical Care Medicine·Alexandra OrtegoMark E Mikkelsen
Mar 10, 2015·Critical Care Medicine·Andrew J GoodwinDee W Ford
Mar 10, 2015·Annals of the American Thoracic Society·Tiffanie K JonesMark E Mikkelsen
Mar 11, 2015·JAMA : the Journal of the American Medical Association·Hallie C PrescottTheodore J Iwashyna
Mar 25, 2015·Critical Care Medicine·Hallie C PrescottTheodore J Iwashyna
Jul 2, 2015·Critical Care Medicine·Dong W ChangMartin F Shapiro
Nov 4, 2015·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Chanu RheeMichael Klompas
Nov 17, 2015·Critical Care Medicine·Alexander SunMark E Mikkelsen
Feb 24, 2016·JAMA : the Journal of the American Medical Association·Mervyn SingerDerek C Angus
Feb 26, 2016·The New England Journal of Medicine·Rachael B ZuckermanArnold M Epstein
May 7, 2016·AACN Advanced Critical Care·Mark E MikkelsenTheodore J Iwashyna
May 28, 2016·Clinics in Chest Medicine·Jason H Maley, Mark E Mikkelsen
Oct 8, 2016·Critical Care : the Official Journal of the Critical Care Forum·C BouzaJ M Amate-Blanco
Oct 27, 2016·The New England Journal of Medicine·Adam C GroffThomas H Lee
Jan 24, 2017·JAMA : the Journal of the American Medical Association·Florian B MayrSachin Yende
Jun 29, 2017·The New England Journal of Medicine·Konrad ReinhartSimon Finfer
Jul 26, 2017·Critical Care Medicine·Kimberley Marie DeMerleHallie C Prescott

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Citations

Oct 10, 2018·Current Opinion in Infectious Diseases·Aaron J HeffernanJason A Roberts
Feb 6, 2019·Journal of Clinical Medicine·June-Sung KimWon Young Kim
Feb 15, 2019·Journal of Clinical Medicine·June-Sung KimWon Young Kim
Oct 24, 2019·Annals of the American Thoracic Society·Stephanie Parks TaylorMarc A Kowalkowski
Feb 15, 2020·Critical Care Medicine·Timothy G BuchmanJeffrey A Kelman
Jun 20, 2020·Archives of Physiology and Biochemistry·Min LiMenghe Wang
Sep 20, 2019·Biological Research for Nursing·Jamie RobinsonJeanne Salyer
Dec 25, 2019·BMC Geriatrics·Andrea FabbriStefano Giovanni Rizzo
Sep 12, 2020·Journal of Intensive Care Medicine·Christopher F ChesleyMark E Mikkelsen
Apr 16, 2019·Critical Care Medicine·Kelly A Cawcutt, Andre C Kalil
Jan 25, 2020·Intensive Care Medicine·Manu Shankar-HariNeill K J Adhikari
Jun 12, 2019·Oxidative Medicine and Cellular Longevity·Jinda HuangQiyi Zeng
Oct 16, 2018·Frontiers in Immunology·Gu-Lung LinAndrew J Pollard
Jan 20, 2019·Critical Care : the Official Journal of the Critical Care Forum·Wen-Kuang YuLorraine B Ware
Feb 23, 2020·World Journal of Emergency Medicine·Wen-Peng YinChun-Sheng Li
Jan 7, 2020·Current Opinion in Anaesthesiology·Jan J De WaeleIsabel Leroux-Roels
Feb 6, 2021·Critical Care : the Official Journal of the Critical Care Forum·Wen-Kuang YuLorraine B Ware
Nov 7, 2020·Journal of the American Geriatrics Society·Brian DownerKenneth Ottenbacher
Apr 16, 2021·BMC Research Notes·Xudong ZhuPatricia C Dykes
Aug 31, 2018·Journal of Clinical Medicine·Joe Alcock
Oct 21, 2020·Journal of Nursing Care Quality·Chris ChimentiJack McIntyre
Jun 7, 2021·Critical Care Medicine·Cheryl MisakMark E Mikkelsen

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