Temporal trends in the characteristics of children at antiretroviral therapy initiation in southern Africa: the IeDEA-SA Collaboration

PloS One
Mary-Ann DaviesIeDEA Southern Africa Steering Group

Abstract

Since 2005, increasing numbers of children have started antiretroviral therapy (ART) in sub-Saharan Africa and, in recent years, WHO and country treatment guidelines have recommended ART initiation for all infants and very young children, and at higher CD4 thresholds for older children. We examined temporal changes in patient and regimen characteristics at ART start using data from 12 cohorts in 4 countries participating in the IeDEA-SA collaboration. Data from 30,300 ART-naïve children aged <16 years at ART initiation who started therapy between 2005 and 2010 were analysed. We examined changes in median values for continuous variables using the Cuzick's test for trend over time. We also examined changes in the proportions of patients with particular disease severity characteristics (expressed as a binary variable e.g. WHO Stage III/IV vs I/II) using logistic regression. Between 2005 and 2010 the number of children starting ART each year increased and median age declined from 63 months (2006) to 56 months (2010). Both the proportion of children <1 year and ≥10 years of age increased from 12 to 19% and 18 to 22% respectively. Children had less severe disease at ART initiation in later years with significant declines in the perce...Continue Reading

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Citations

Jan 1, 2014·The Pediatric Infectious Disease Journal·Mary-Ann DaviesUNKNOWN IeDEA Southern Africa Collaboration
Jul 9, 2016·AIDS Care·Arvin BhanaMary McKay
Jan 10, 2017·Tropical Medicine & International Health : TM & IH·Zenebe MelakuElaine J Abrams
May 23, 2017·Journal of the International AIDS Society·Amy L SlogroveMary-Ann Davies
Jan 1, 2015·Journal of the International AIDS Society·Mary-Ann DaviesMarlène Bras
Dec 8, 2015·Journal of the International AIDS Society·Elaine J Abrams, Susan Strasser
Oct 8, 2016·Current Opinion in HIV and AIDS·Mary-Ann DaviesAnna Turkova
Mar 8, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Lisa FrigatiNathan Ford
Jan 8, 2019·Journal of the International AIDS Society·Klea PanayidouUNKNOWN IeDEA, COHERE, PHACS and IMPAACT 219C Collaborations Writing Group
Jun 3, 2017·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·David P MooreShabir A Madhi
Apr 17, 2020·Frontiers in Public Health·Tendai MunthaliJim Todd
Aug 26, 2017·The Pediatric Infectious Disease Journal·Francis Ateba NdongoUNKNOWN ANRS-Pediacam Study Group

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Methods Mentioned

BETA
PCR

Software Mentioned

STATA

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