Temporal Trends in the Incidence of and Mortality Associated With Heart Failure With Preserved and Reduced Ejection Fraction

JACC. Heart Failure
Connie W TsaoRamachandran S Vasan

Abstract

This study aimed to determine temporal trends in the incidence of and mortality associated with heart failure (HF) and its subtypes (heart failure with reduced ejection fraction [HFrEF] and heart rate with preserved ejection fraction [HFpEF]) in the community. Major shifts in cardiovascular disease risk factor prevalence and advances in therapies may have influenced HF incidence and mortality. In the FHS (Framingham Heart Study) and CHS (Cardiovascular Health Study), for participants who were ≥60 years of age and free of HF (n = 15,217; 60% women; 2,524 incident HF cases; 115,703 person-years of follow-up), we estimated adjusted incidence rate ratios of HF, HFrEF, and HFpEF from 1990 to 1999 and 2000 to 2009. We compared the cumulative incidence of and mortality associated with HFrEF versus HFpEF within and between decades. Across the 2 decades, HF incidence rate ratio was similar (p = 0.13). The incidence rate ratio of HFrEF declined (p = 0.0029), whereas HFpEF increased (p < 0.001). Although HFrEF incidence declined more in men than in women, men had a higher incidence of HFrEF than women in each decade (p < 0.001). The incidence of HFpEF significantly increased over time in both men and women (p < 0.001 and p = 0.02, respect...Continue Reading

Citations

May 9, 2019·Nature Reviews. Cardiology·Charlotte AnderssonRamachandran S Vasan
May 24, 2019·Circulation Research·Islam Y ElgendyCarl J Pepine
Feb 18, 2020·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Susan StienenPatrick Rossignol
Jan 8, 2020·European Journal of Heart Failure·Maria TamargoBarry A Borlaug
Jun 3, 2020·European Journal of Heart Failure·Amy GroenewegenArno W Hoes
Aug 5, 2020·JAMA : the Journal of the American Medical Association·Sean P MurphyJames L Januzzi
Aug 22, 2020·American Journal of Physiology. Heart and Circulatory Physiology·Karim KadryNikos Stergiopulos
Aug 25, 2020·Biology of Sex Differences·Susan StienenPatrick Rossignol
Sep 27, 2018·Current Heart Failure Reports·Nadia Bouabdallaoui, Anique Ducharme
Apr 8, 2020·Cardiac Failure Review·Veronika ZachFrank Edelmann
Jul 6, 2020·Current Hypertension Reports·Karnika AyinapudiSuzanne Oparil
May 22, 2019·Current Cardiology Reports·Jamshid ShiraniVasken Dilsizian
Sep 14, 2019·JAMA : the Journal of the American Medical Association·Javed ButlerMilton Packer
Jul 11, 2020·Current Cardiology Reports·Daria M AdamczakEwa Straburzyńska-Migaj
Nov 21, 2019·European Journal of Heart Failure·Amy Groenewegen, Frans H Rutten
Oct 28, 2020·Annals of Medicine·Emily BrownDaniel J Cuthbertson
Jan 14, 2021·Scientific Reports·Giosafat SpitaleriAntoni Bayes-Genis
Dec 31, 2020·Healthcare·Clemens Scott KruseLawrence V Fulton
Oct 10, 2020·Journal of Cardiac Failure·Jasleen GhumanRupal Mehta
Apr 29, 2021·Heart Failure Reviews·Giacomo TiniIacopo Olivotto
May 9, 2021·European Journal of Preventive Cardiology·Francesco GentileAlberto Giannoni
May 14, 2021·Circulation Research·Véronique L Roger
Jun 1, 2021·Journal of the American Heart Association·Rohan Samson, Thierry H Le Jemtel
May 25, 2021·Frontiers in Cardiovascular Medicine·Marta FarreroBeatriz Díaz Molina
May 31, 2021·Heart Failure Clinics·Dong-Hyuk Cho, Byung-Su Yoo
Jul 3, 2021·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Andrea Del CampoHugo E Verdejo

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