Temporal trends of phthalate exposures during 2007-2010 in Swedish pregnant women

Journal of Exposure Science & Environmental Epidemiology
Huan ShuCarl-Gustaf Bornehag

Abstract

The general population is exposed to phthalates, a group of chemicals with strong evidence for endocrine disrupting properties, commonly used in a large number of consumer products. Based on published research and evidence compiled by environmental agencies, certain phthalate applications and products have become restricted, leading to an increasing number of "new generation compounds" coming onto the market during recent years replacing older phthalates. Some examples of such newer compounds are di-iso-nonyl phthalate (DiNP), di-iso-decyl phthalate (DiDP), and most recently di-isononyl-cyclohexane-1,2-dicarboxylate (DiNCH). In order to evaluate temporal trends in phthalate exposure, first trimester urinary biomarkers of phthalates were measured in the Swedish SELMA study over a period of 2.5 years (2007-2010). We collected first morning void urine samples around week 10 of pregnancy from 1651 pregnant women. Spot samples were analyzed for 13 phthalate metabolites and one phthalate replacement and least square geometric mean (LSGM) levels of the metabolites were compared between the sampling years when adjusted for potential confounders. All 14 metabolites were detectable in more than 99% of the SELMA subjects. The levels were ...Continue Reading

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Citations

Mar 26, 2019·JAMA Pediatrics·Rainer OtterGerard Swaen
Jun 8, 2019·Risk Analysis : an Official Publication of the Society for Risk Analysis·Carl-Gustaf BornehagChris Gennings
Sep 5, 2019·Journal of Exposure Science & Environmental Epidemiology·Yanelli Rodríguez-CarmonaDeborah Watkins
Dec 14, 2019·Toxicologic Pathology·Scott M BelcherJeffrey C Wolf
Oct 24, 2019·Journal of Exposure Science & Environmental Epidemiology·Garthika NavaranjanJeffrey R Brook
Sep 22, 2020·Journal of Exposure Science & Environmental Epidemiology·Anna-Sofia PreeceCarl-Gustaf Bornehag
Aug 9, 2020·Environment International·Margaret A AdgentSheela Sathyanarayana
Feb 2, 2021·Environment International·Giehae ChoiStephanie M Engel
Mar 12, 2021·Neurotoxicology·Kelsey L C DzwilewskiSusan L Schantz
Sep 4, 2021·Journal of Exposure Science & Environmental Epidemiology·Anna-Sofia PreeceHuan Shu

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